a tool for identifying drug-targetable redox-active disulphides

ABO glycosyltransferase

Intermolecular

Cysteine 70 and cysteine 70

A redox-regulated disulphide may form between two units of ABO glycosyltransferase at cysteines 70 and 70 (80 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

32

PDB code

Structure name

crystal structure of unliganded gtb p156l

Structure deposition date

2011-01-31

Thiol separation (Å)

10

Half-sphere exposure sum ?

70

Minimum pK_a ?

11

% buried

86

Peptide A name

ABO glycosyltransferase

Peptide B name

ABO glycosyltransferase

Peptide A accession

Peptide B accession

Peptide A residue number

70

Peptide B residue number

70

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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