ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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BTB/POZ domain-containing protein KCTD1

Intermolecular
Cysteine 221 and cysteine 221
Intramolecular
Cysteine 140 and cysteine 142
A redox-regulated disulphide may form between two units of BTB/POZ domain-containing protein KCTD1 at cysteines 221 and 221. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6s4l
Structure name
structure of human kctd1
Structure deposition date
2019-06-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
106
Minimum pKa ?
13
% buried
100
Peptide A name
BTB/POZ domain-containing protein KCTD1
Peptide B name
BTB/POZ domain-containing protein KCTD1
Peptide A accession
Q719H9
Peptide B accession
Q719H9
Peptide A residue number
221
Peptide B residue number
221

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within BTB/POZ domain-containing protein KCTD1 between cysteines 140 and 142.

Details

Redox score ?
70
PDB code
6s4l
Structure name
structure of human kctd1
Structure deposition date
2019-06-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
85
Peptide accession
Q719H9
Residue number A
140
Residue number B
142
Peptide name
BTB/POZ domain-containing protein KCTD1

Ligandability

Cysteine 140 of BTB/POZ domain-containing protein KCTD1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of BTB/POZ domain-containing protein KCTD1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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