Mediator of RNA polymerase II transcription subunit 25

Intramolecular

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 25 between cysteines 111 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7emf

Structure name

human mediator (deletion of med1-idr) in a tail-extended conformation

Structure deposition date

2021-04-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q71SY5

Residue number A

111

Residue number B

146

Peptide name

Mediator of RNA polymerase II transcription subunit 25

Ligandability

Cysteine 111 of Mediator of RNA polymerase II transcription subunit 25

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.