ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrator complex subunit 8

Intramolecular
Cysteine 888 and cysteine 893
Cysteine 887 and cysteine 888
Cysteine 381 and cysteine 385
Cysteine 385 and cysteine 387
Cysteine 888 and cysteine 901
A redox-regulated disulphide may form within Integrator complex subunit 8 between cysteines 888 and 893. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
13
% buried
100
Peptide accession
Q75QN2
Residue number A
888
Residue number B
893
Peptide name
Integrator complex subunit 8

Ligandability

Cysteine 888 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 893 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 8 between cysteines 887 and 888. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
94
Peptide accession
Q75QN2
Residue number A
887
Residue number B
888
Peptide name
Integrator complex subunit 8

Ligandability

Cysteine 887 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 888 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 8 between cysteines 381 and 385. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
93
Peptide accession
Q75QN2
Residue number A
381
Residue number B
385
Peptide name
Integrator complex subunit 8

Ligandability

Cysteine 381 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 8 between cysteines 385 and 387. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
90
Peptide accession
Q75QN2
Residue number A
385
Residue number B
387
Peptide name
Integrator complex subunit 8

Ligandability

Cysteine 385 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrator complex subunit 8 between cysteines 888 and 901. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide accession
Q75QN2
Residue number A
888
Residue number B
901
Peptide name
Integrator complex subunit 8

Ligandability

Cysteine 888 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 901 of Integrator complex subunit 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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