ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ORF 73

Intermolecular
Cysteine 261 of WD repeat-containing protein 5 and cysteine 23
Cysteine 134 of WD repeat-containing protein 5 and cysteine 23
A redox-regulated disulphide may form between cysteine 261 of WD repeat-containing protein 5 and cysteine 23 of ORF 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7bcy
Structure name
x-ray structure of wdr5delta24 bound to the kaposi's sarcoma herpesvirus lana win motif peptide
Structure deposition date
2020-12-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
100
Peptide A name
WD repeat-containing protein 5
Peptide B name
ORF 73
Peptide A accession
P61964
Peptide B accession
Q76SB0
Peptide A residue number
261
Peptide B residue number
23

Ligandability

Cysteine 261 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 23 of ORF 73

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 134 of WD repeat-containing protein 5 and cysteine 23 of ORF 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7bcy
Structure name
x-ray structure of wdr5delta24 bound to the kaposi's sarcoma herpesvirus lana win motif peptide
Structure deposition date
2020-12-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
96
Peptide A name
WD repeat-containing protein 5
Peptide B name
ORF 73
Peptide A accession
P61964
Peptide B accession
Q76SB0
Peptide A residue number
134
Peptide B residue number
23

Ligandability

Cysteine 134 of WD repeat-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 23 of ORF 73

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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