ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription elongation factor SPT6

Intramolecular
Cysteine 1169 and cysteine 1265
Cysteine 1435 and cysteine 1463 L
Cysteine 1265 and cysteine 1281
Cysteine 1169 and cysteine 1281
Cysteine 931 and cysteine 939
Cysteine 990 and cysteine 1031
Cysteine 1463 and cysteine 1465 L
Cysteine 1021 and cysteine 1031
A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 1169 and 1265.

Details

Redox score ?
80
PDB code
7oop
Structure name
pol ii-csb-csa-ddb1-uvssa-paf-spt6 (structure 3)
Structure deposition date
2021-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
58
Peptide accession
Q7KZ85
Residue number A
1169
Residue number B
1265
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 1169 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1265 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 1435 and 1463.

Details

Redox score ?
75
PDB code
6gme
Structure name
structure of h
Structure deposition date
2018-05-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
63
Peptide accession
Q7KZ85
Residue number A
1435
Residue number B
1463
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 1435 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1463 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 1265 and 1281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7opd
Structure name
pol ii-csb-crl4csa-uvssa-spt6-paf (structure 5)
Structure deposition date
2021-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
56
Peptide accession
Q7KZ85
Residue number A
1265
Residue number B
1281
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 1265 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1281 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 1169 and 1281. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7opc
Structure name
pol ii-csb-crl4csa-uvssa-spt6-paf (structure 4)
Structure deposition date
2021-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
52
Peptide accession
Q7KZ85
Residue number A
1169
Residue number B
1281
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 1169 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1281 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 931 and 939. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7oop
Structure name
pol ii-csb-csa-ddb1-uvssa-paf-spt6 (structure 3)
Structure deposition date
2021-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
55
Peptide accession
Q7KZ85
Residue number A
931
Residue number B
939
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 931 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 939 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 990 and 1031. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7opc
Structure name
pol ii-csb-crl4csa-uvssa-spt6-paf (structure 4)
Structure deposition date
2021-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
101
Minimum pKa ?
12
% buried
100
Peptide accession
Q7KZ85
Residue number A
990
Residue number B
1031
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 990 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 1463 and 1465. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6gme
Structure name
structure of h
Structure deposition date
2018-05-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
86
Peptide accession
Q7KZ85
Residue number A
1463
Residue number B
1465
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 1463 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 1465 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription elongation factor SPT6 between cysteines 1021 and 1031. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7oop
Structure name
pol ii-csb-csa-ddb1-uvssa-paf-spt6 (structure 3)
Structure deposition date
2021-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
75
Peptide accession
Q7KZ85
Residue number A
1021
Residue number B
1031
Peptide name
Transcription elongation factor SPT6

Ligandability

Cysteine 1021 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Transcription elongation factor SPT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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