ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Volume-regulated anion channel subunit LRRC8D

Intermolecular
Cysteine 809 and cysteine 687
Intramolecular
Cysteine 54 and cysteine 354
Cysteine 153 and cysteine 339
Cysteine 54 and cysteine 153
Cysteine 521 and cysteine 523
Cysteine 153 and cysteine 354
Cysteine 339 and cysteine 354
Cysteine 54 and cysteine 339
Cysteine 786 and cysteine 809
Cysteine 687 and cysteine 733
A redox-regulated disulphide may form between two units of Volume-regulated anion channel subunit LRRC8D at cysteines 809 and 687. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
90
Peptide A name
Volume-regulated anion channel subunit LRRC8D
Peptide B name
Volume-regulated anion channel subunit LRRC8D
Peptide A accession
Q7L1W4
Peptide B accession
Q7L1W4
Peptide A residue number
809
Peptide B residue number
687

Ligandability

Cysteine 809 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 687 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 54 and 354.

Details

Redox score ?
82
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7L1W4
Residue number A
54
Residue number B
354
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 153 and 339.

Details

Redox score ?
71
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
56
Peptide accession
Q7L1W4
Residue number A
153
Residue number B
339
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 153 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 54 and 153.

Details

Redox score ?
68
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
nan
Peptide accession
Q7L1W4
Residue number A
54
Residue number B
153
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 521 and 523.

Details

Redox score ?
61
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
58
Peptide accession
Q7L1W4
Residue number A
521
Residue number B
523
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 521 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 523 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 153 and 354.

Details

Redox score ?
61
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
16
% buried
nan
Peptide accession
Q7L1W4
Residue number A
153
Residue number B
354
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 153 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 339 and 354.

Details

Redox score ?
61
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
nan
Peptide accession
Q7L1W4
Residue number A
339
Residue number B
354
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 339 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 54 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
nan
Peptide accession
Q7L1W4
Residue number A
54
Residue number B
339
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 786 and 809. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
92
Peptide accession
Q7L1W4
Residue number A
786
Residue number B
809
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 786 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 809 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8D between cysteines 687 and 733. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6m04
Structure name
structure of the human homo-hexameric lrrc8d channel at 4
Structure deposition date
2020-02-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
44
Peptide accession
Q7L1W4
Residue number A
687
Residue number B
733
Peptide name
Volume-regulated anion channel subunit LRRC8D

Ligandability

Cysteine 687 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 733 of Volume-regulated anion channel subunit LRRC8D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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