ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RAS guanyl-releasing protein 2

Intramolecular
Cysteine 11 and cysteine 20
A redox-regulated disulphide may form within RAS guanyl-releasing protein 2 between cysteines 11 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6axf
Structure name
structure of rasgrp2 in complex with rap1b
Structure deposition date
2017-09-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
54
Peptide accession
Q7LDG7
Residue number A
11
Residue number B
20
Peptide name
RAS guanyl-releasing protein 2

Ligandability

Cysteine 11 of RAS guanyl-releasing protein 2

Cysteine 20 of RAS guanyl-releasing protein 2

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