ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CXXC-type zinc finger protein 5

Intramolecular
Cysteine 278 and cysteine 281
Cysteine 266 and cysteine 269
Cysteine 275 and cysteine 278
Cysteine 281 and cysteine 291
Cysteine 263 and cysteine 296
Cysteine 266 and cysteine 296
Cysteine 263 and cysteine 266
Cysteine 269 and cysteine 296
Cysteine 275 and cysteine 291
Cysteine 278 and cysteine 291
More...
Cysteine 275 and cysteine 281
Cysteine 263 and cysteine 269
A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 278 and 281.

Details

Redox score ?
78
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
278
Residue number B
281
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 278 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 266 and 269.

Details

Redox score ?
77
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
266
Residue number B
269
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 266 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 275 and 278.

Details

Redox score ?
77
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
275
Residue number B
278
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 275 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 281 and 291.

Details

Redox score ?
76
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
281
Residue number B
291
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 281 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 263 and 296.

Details

Redox score ?
76
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
263
Residue number B
296
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 263 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 266 and 296.

Details

Redox score ?
76
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
266
Residue number B
296
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 266 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 263 and 266.

Details

Redox score ?
76
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
263
Residue number B
266
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 263 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 269 and 296.

Details

Redox score ?
75
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
269
Residue number B
296
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 269 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 275 and 291.

Details

Redox score ?
75
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
275
Residue number B
291
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 275 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 278 and 291.

Details

Redox score ?
75
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
278
Residue number B
291
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 278 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 275 and 281.

Details

Redox score ?
74
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
275
Residue number B
281
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 275 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CXXC-type zinc finger protein 5 between cysteines 263 and 269.

Details

Redox score ?
74
PDB code
5w9s
Structure name
zinc finger of human cxxc5 in complex with cpg dna
Structure deposition date
2017-06-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7LFL8
Residue number A
263
Residue number B
269
Peptide name
CXXC-type zinc finger protein 5

Ligandability

Cysteine 263 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of CXXC-type zinc finger protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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