a tool for identifying drug-targetable redox-active disulphides

Ribonucleoside-diphosphate reductase subunit M2 B

Intramolecular

Cysteine 232 and cysteine 236

A redox-regulated disulphide may form within Ribonucleoside-diphosphate reductase subunit M2 B between cysteines 232 and 236.

Details

Redox score ?

67

PDB code

Structure name

crystal structure of human p53r2

Structure deposition date

2009-05-10

Thiol separation (Å)

4

Half-sphere exposure sum ?

73

Minimum pK_a ?

9

% buried

90

Peptide accession

Residue number A

232

Residue number B

236

Peptide name

Ribonucleoside-diphosphate reductase subunit M2 B

Ligandability

Cysteine 232 of Ribonucleoside-diphosphate reductase subunit M2 B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of Ribonucleoside-diphosphate reductase subunit M2 B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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