ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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STE20-related kinase adapter protein alpha

Intramolecular
Cysteine 270 and cysteine 298
Cysteine 270 and cysteine 359
A redox-regulated disulphide may form within STE20-related kinase adapter protein alpha between cysteines 270 and 298.

Details

Redox score ?
62
PDB code
2wtk
Structure name
structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex
Structure deposition date
2009-09-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
38
Peptide accession
Q7RTN6
Residue number A
270
Residue number B
298
Peptide name
STE20-related kinase adapter protein alpha

Ligandability

Cysteine 270 of STE20-related kinase adapter protein alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of STE20-related kinase adapter protein alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within STE20-related kinase adapter protein alpha between cysteines 270 and 359. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2wtk
Structure name
structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex
Structure deposition date
2009-09-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
88
Peptide accession
Q7RTN6
Residue number A
270
Residue number B
359
Peptide name
STE20-related kinase adapter protein alpha

Ligandability

Cysteine 270 of STE20-related kinase adapter protein alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 359 of STE20-related kinase adapter protein alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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