PHD finger-like domain-containing protein 5A
Intermolecular
Cysteine 677 of Splicing factor 3B subunit 1 and cysteine 11
Cysteine 677 of Splicing factor 3B subunit 1 and cysteine 85
Cysteine 677 of Splicing factor 3B subunit 1 and cysteine 46 L
Cysteine 677 of Splicing factor 3B subunit 1 and cysteine 49 L
Intramolecular
Cysteine 23 and cysteine 26
Cysteine 58 and cysteine 61 L
Cysteine 11 and cysteine 46 L
Cysteine 30 and cysteine 72 L
Cysteine 23 and cysteine 58 L
Cysteine 11 and cysteine 49 L
More...Cysteine 46 and cysteine 49 L
Cysteine 23 and cysteine 61
Cysteine 26 and cysteine 58 L
Cysteine 33 and cysteine 72 L
Cysteine 30 and cysteine 33
Cysteine 11 and cysteine 85
Cysteine 72 and cysteine 75 L
Cysteine 46 and cysteine 85 L
Cysteine 26 and cysteine 61
Cysteine 33 and cysteine 75
Cysteine 40 and cysteine 72 L
Cysteine 49 and cysteine 85 L
Cysteine 30 and cysteine 75
Cysteine 30 and cysteine 40
Cysteine 40 and cysteine 75
5z58 1 677 6 11
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 11 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5z58
Structure name
cryo-em structure of a human activated spliceosome (early bact) at 4
Structure deposition date
2018-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
64
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
11
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 11 of PHD finger-like domain-containing protein 5A
5z58 1 677 6 85
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 85 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5z58
Structure name
cryo-em structure of a human activated spliceosome (early bact) at 4
Structure deposition date
2018-01-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
70
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
85
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 85 of PHD finger-like domain-containing protein 5A
7q4o A 677 G 46
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 46 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7q4o
Structure name
substrate-bound a-like u2 snrnp
Structure deposition date
2021-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
48
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
46
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 46 of PHD finger-like domain-containing protein 5A
7q4o A 677 G 49
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 49 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7q4o
Structure name
substrate-bound a-like u2 snrnp
Structure deposition date
2021-11-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
42
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
49
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 49 of PHD finger-like domain-containing protein 5A
5syb A 23 A 26
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 23 and 26.
Details
Redox score ?
84
PDB code
5syb
Structure name
crystal structure of human phf5a
Structure deposition date
2016-08-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
4
Peptide accession
Q7RTV0
Residue number A
23
Residue number B
26
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 23 of PHD finger-like domain-containing protein 5A
Cysteine 26 of PHD finger-like domain-containing protein 5A
7b91 D 58 D 61
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 58 and 61.
Details
Redox score ?
83
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
5
% buried
34
Peptide accession
Q7RTV0
Residue number A
58
Residue number B
61
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 58 of PHD finger-like domain-containing protein 5A
Cysteine 61 of PHD finger-like domain-containing protein 5A
7b0i D 11 D 46
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 11 and 46.
Details
Redox score ?
82
PDB code
7b0i
Structure name
structure of a minimal sf3b core in complex with spliceostatin a (form ii)
Structure deposition date
2020-11-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
nan
Peptide accession
Q7RTV0
Residue number A
11
Residue number B
46
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 11 of PHD finger-like domain-containing protein 5A
Cysteine 46 of PHD finger-like domain-containing protein 5A
5syb B 30 B 72
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 30 and 72.
Details
Redox score ?
82
PDB code
5syb
Structure name
crystal structure of human phf5a
Structure deposition date
2016-08-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
22
Peptide accession
Q7RTV0
Residue number A
30
Residue number B
72
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 30 of PHD finger-like domain-containing protein 5A
Cysteine 72 of PHD finger-like domain-containing protein 5A
7b92 D 23 D 58
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 23 and 58.
Details
Redox score ?
81
PDB code
7b92
Structure name
structure of a minimal sf3b core in complex with sudemycin d6 (form ii)
Structure deposition date
2020-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
36
Peptide accession
Q7RTV0
Residue number A
23
Residue number B
58
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 23 of PHD finger-like domain-containing protein 5A
Cysteine 58 of PHD finger-like domain-containing protein 5A
6en4 D 11 D 49
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 11 and 49.
Details
Redox score ?
81
PDB code
6en4
Structure name
sf3b core in complex with a splicing modulator
Structure deposition date
2017-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
5
% buried
65
Peptide accession
Q7RTV0
Residue number A
11
Residue number B
49
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 11 of PHD finger-like domain-containing protein 5A
Cysteine 49 of PHD finger-like domain-containing protein 5A
7b91 D 46 D 49
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 46 and 49.
Details
Redox score ?
80
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
6
% buried
63
Peptide accession
Q7RTV0
Residue number A
46
Residue number B
49
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 46 of PHD finger-like domain-containing protein 5A
Cysteine 49 of PHD finger-like domain-containing protein 5A
7b91 D 23 D 61
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 23 and 61.
Details
Redox score ?
80
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
19
Peptide accession
Q7RTV0
Residue number A
23
Residue number B
61
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 23 of PHD finger-like domain-containing protein 5A
Cysteine 61 of PHD finger-like domain-containing protein 5A
7b91 D 26 D 58
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 26 and 58.
Details
Redox score ?
79
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
5
% buried
42
Peptide accession
Q7RTV0
Residue number A
26
Residue number B
58
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 26 of PHD finger-like domain-containing protein 5A
Cysteine 58 of PHD finger-like domain-containing protein 5A
6en4 D 33 D 72
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 33 and 72.
Details
Redox score ?
79
PDB code
6en4
Structure name
sf3b core in complex with a splicing modulator
Structure deposition date
2017-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
85
Peptide accession
Q7RTV0
Residue number A
33
Residue number B
72
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 33 of PHD finger-like domain-containing protein 5A
Cysteine 72 of PHD finger-like domain-containing protein 5A
6en4 D 30 D 33
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 30 and 33.
Details
Redox score ?
78
PDB code
6en4
Structure name
sf3b core in complex with a splicing modulator
Structure deposition date
2017-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
nan
Peptide accession
Q7RTV0
Residue number A
30
Residue number B
33
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 30 of PHD finger-like domain-containing protein 5A
Cysteine 33 of PHD finger-like domain-containing protein 5A
5syb B 11 B 85
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 11 and 85.
Details
Redox score ?
77
PDB code
5syb
Structure name
crystal structure of human phf5a
Structure deposition date
2016-08-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
6
% buried
68
Peptide accession
Q7RTV0
Residue number A
11
Residue number B
85
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 11 of PHD finger-like domain-containing protein 5A
Cysteine 85 of PHD finger-like domain-containing protein 5A
7omf D 72 D 75
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 72 and 75.
Details
Redox score ?
77
PDB code
7omf
Structure name
structure of a minimal sf3b core in complex with sudemycin d6 (form i)
Structure deposition date
2021-05-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
75
Peptide accession
Q7RTV0
Residue number A
72
Residue number B
75
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 72 of PHD finger-like domain-containing protein 5A
Cysteine 75 of PHD finger-like domain-containing protein 5A
6en4 D 46 D 85
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 46 and 85.
Details
Redox score ?
75
PDB code
6en4
Structure name
sf3b core in complex with a splicing modulator
Structure deposition date
2017-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
5
% buried
69
Peptide accession
Q7RTV0
Residue number A
46
Residue number B
85
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 46 of PHD finger-like domain-containing protein 5A
Cysteine 85 of PHD finger-like domain-containing protein 5A
5ife D 26 D 61
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 26 and 61.
Details
Redox score ?
75
PDB code
5ife
Structure name
crystal structure of the human sf3b core complex
Structure deposition date
2016-02-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
18
Peptide accession
Q7RTV0
Residue number A
26
Residue number B
61
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 26 of PHD finger-like domain-containing protein 5A
Cysteine 61 of PHD finger-like domain-containing protein 5A
7b91 D 33 D 75
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 33 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
15
% buried
84
Peptide accession
Q7RTV0
Residue number A
33
Residue number B
75
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 33 of PHD finger-like domain-containing protein 5A
Cysteine 75 of PHD finger-like domain-containing protein 5A
7opi D 40 D 72
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 40 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7opi
Structure name
structure of a minimal sf3b core in complex with the inactive modulator spliceostatin e (form i)
Structure deposition date
2021-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
70
Peptide accession
Q7RTV0
Residue number A
40
Residue number B
72
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 40 of PHD finger-like domain-containing protein 5A
Cysteine 72 of PHD finger-like domain-containing protein 5A
7b91 D 49 D 85
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 49 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
23
% buried
nan
Peptide accession
Q7RTV0
Residue number A
49
Residue number B
85
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 49 of PHD finger-like domain-containing protein 5A
Cysteine 85 of PHD finger-like domain-containing protein 5A
5ife D 30 D 75
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 30 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5ife
Structure name
crystal structure of the human sf3b core complex
Structure deposition date
2016-02-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
24
% buried
nan
Peptide accession
Q7RTV0
Residue number A
30
Residue number B
75
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 30 of PHD finger-like domain-containing protein 5A
Cysteine 75 of PHD finger-like domain-containing protein 5A
7b9c D 30 D 40
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 30 and 40. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7b9c
Structure name
structure of a minimal sf3b core in complex with spliceostatin a (form i)
Structure deposition date
2020-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
nan
Peptide accession
Q7RTV0
Residue number A
30
Residue number B
40
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 30 of PHD finger-like domain-containing protein 5A
Cysteine 40 of PHD finger-like domain-containing protein 5A
7b91 D 40 D 75
A redox-regulated disulphide may form within PHD finger-like domain-containing protein 5A between cysteines 40 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7b91
Structure name
structure of a minimal sf3b core in complex with pladienolide d (form i)
Structure deposition date
2020-12-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
76
Peptide accession
Q7RTV0
Residue number A
40
Residue number B
75
Peptide name
PHD finger-like domain-containing protein 5A
Ligandability
Cysteine 40 of PHD finger-like domain-containing protein 5A
Cysteine 75 of PHD finger-like domain-containing protein 5A
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