ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anti-colorectal carcinoma light chain

Intramolecular
Cysteine 45 and cysteine 110
Cysteine 156 and cysteine 216
A redox-regulated disulphide may form within Anti-colorectal carcinoma light chain between cysteines 45 and 110 (23 and 88 respectively in this structure).

Details

Redox score ?
80
PDB code
5tr8
Structure name
crystal structure of vaccine-elicited pan- influenza h1n1 neutralizing murine antibody 441d6
Structure deposition date
2016-10-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7TS98
Residue number A
45
Residue number B
110
Peptide name
Anti-colorectal carcinoma light chain

Ligandability

Cysteine 45 of Anti-colorectal carcinoma light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Anti-colorectal carcinoma light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-colorectal carcinoma light chain between cysteines 156 and 216 (134 and 194 respectively in this structure).

Details

Redox score ?
78
PDB code
4kvc
Structure name
2h2 fab fragment of immature dengue virus
Structure deposition date
2013-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7TS98
Residue number A
156
Residue number B
216
Peptide name
Anti-colorectal carcinoma light chain

Ligandability

Cysteine 156 of Anti-colorectal carcinoma light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Anti-colorectal carcinoma light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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