ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Aprataxin

Intramolecular
Cysteine 333 and cysteine 336
Cysteine 19 and cysteine 65
A redox-regulated disulphide may form within Aprataxin between cysteines 333 and 336 (319 and 322 respectively in this structure).

Details

Redox score ?
85
PDB code
6cvt
Structure name
human aprataxin (aptx) v263g bound to rna-dna, amp and zn product complex
Structure deposition date
2018-03-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
14
Peptide accession
Q7Z2E3
Residue number A
333
Residue number B
336
Peptide name
Aprataxin

Ligandability

Cysteine 333 of Aprataxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Aprataxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aprataxin between cysteines 19 and 65 (5 and 51 respectively in this structure).

Details

Redox score ?
68
PDB code
3kt9
Structure name
aprataxin fha domain
Structure deposition date
2009-11-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
37
Peptide accession
Q5T784
Residue number A
19
Residue number B
65
Peptide name
Aprataxin

Ligandability

Cysteine 19 of Aprataxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Aprataxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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