Transient receptor potential cation channel subfamily M member 8
Intramolecular
Cysteine 929 and cysteine 940
Cysteine 303 and cysteine 326
Cysteine 1031 and cysteine 1032
Cysteine 1028 and cysteine 1031
Cysteine 698 and cysteine 707
Cysteine 1028 and cysteine 1032
Cysteine 122 and cysteine 267
Cysteine 648 and cysteine 656
Cysteine 587 and cysteine 648
Cysteine 587 and cysteine 632
More...Cysteine 632 and cysteine 656
Cysteine 587 and cysteine 656
7wrd C 929 C 940
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 929 and 940.
Details
Redox score ?
85
PDB code
7wrd
Structure name
mouse trpm8 in lmng in the presence of calcium and icilin
Structure deposition date
2022-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8R4D5
Residue number A
929
Residue number B
940
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 929 of Transient receptor potential cation channel subfamily M member 8
Cysteine 940 of Transient receptor potential cation channel subfamily M member 8
8e4l D 303 D 326
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 303 and 326.
Details
Redox score ?
72
PDB code
8e4l
Structure name
the open state mouse trpm8 structure in complex with the cooling agonist c3, aitc, and pi(4,5)p2
Structure deposition date
2022-08-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
93
Minimum pKa ?
8
% buried
100
Peptide accession
Q8R4D5
Residue number A
303
Residue number B
326
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 303 of Transient receptor potential cation channel subfamily M member 8
Cysteine 326 of Transient receptor potential cation channel subfamily M member 8
8e4p C 1031 C 1032
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 1031 and 1032.
Details
Redox score ?
65
PDB code
8e4p
Structure name
mouse trpm8 structure determined in the ligand- and pi(4,5)p2-free condition, class i , c0 state
Structure deposition date
2022-08-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q8R4D5
Residue number A
1031
Residue number B
1032
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 1031 of Transient receptor potential cation channel subfamily M member 8
Cysteine 1032 of Transient receptor potential cation channel subfamily M member 8
8e4p A 1028 A 1031
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 1028 and 1031.
Details
Redox score ?
60
PDB code
8e4p
Structure name
mouse trpm8 structure determined in the ligand- and pi(4,5)p2-free condition, class i , c0 state
Structure deposition date
2022-08-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
21
Minimum pKa ?
9
% buried
0
Peptide accession
Q8R4D5
Residue number A
1028
Residue number B
1031
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 1028 of Transient receptor potential cation channel subfamily M member 8
Cysteine 1031 of Transient receptor potential cation channel subfamily M member 8
7wra B 698 B 707
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 698 and 707. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
7wra
Structure name
mouse trpm8 in lmng in ligand-free state
Structure deposition date
2022-01-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
10
Peptide accession
Q8R4D5
Residue number A
698
Residue number B
707
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 698 of Transient receptor potential cation channel subfamily M member 8
Cysteine 707 of Transient receptor potential cation channel subfamily M member 8
8e4p B 1028 B 1032
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 1028 and 1032. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
8e4p
Structure name
mouse trpm8 structure determined in the ligand- and pi(4,5)p2-free condition, class i , c0 state
Structure deposition date
2022-08-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q8R4D5
Residue number A
1028
Residue number B
1032
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 1028 of Transient receptor potential cation channel subfamily M member 8
Cysteine 1032 of Transient receptor potential cation channel subfamily M member 8
8e4n D 122 D 267
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 122 and 267. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
8e4n
Structure name
the closed c1-state mouse trpm8 structure in complex with pi(4,5)p2
Structure deposition date
2022-08-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
0
Peptide accession
Q8R4D5
Residue number A
122
Residue number B
267
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 122 of Transient receptor potential cation channel subfamily M member 8
Cysteine 267 of Transient receptor potential cation channel subfamily M member 8
8e4l B 648 B 656
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 648 and 656. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
8e4l
Structure name
the open state mouse trpm8 structure in complex with the cooling agonist c3, aitc, and pi(4,5)p2
Structure deposition date
2022-08-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
73
Peptide accession
Q8R4D5
Residue number A
648
Residue number B
656
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 648 of Transient receptor potential cation channel subfamily M member 8
Cysteine 656 of Transient receptor potential cation channel subfamily M member 8
7wrc C 587 C 648
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 587 and 648. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7wrc
Structure name
mouse trpm8 in lmng in the presence of calcium, icilin and pi(4,5)p2
Structure deposition date
2022-01-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
84
Peptide accession
Q8R4D5
Residue number A
587
Residue number B
648
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 587 of Transient receptor potential cation channel subfamily M member 8
Cysteine 648 of Transient receptor potential cation channel subfamily M member 8
8e4m C 587 C 632
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 587 and 632. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
8e4m
Structure name
the intermediate c2-state mouse trpm8 structure in complex with the cooling agonist c3 and pi(4,5)p2
Structure deposition date
2022-08-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
90
Peptide accession
Q8R4D5
Residue number A
587
Residue number B
632
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 587 of Transient receptor potential cation channel subfamily M member 8
Cysteine 632 of Transient receptor potential cation channel subfamily M member 8
7wrd B 632 B 656
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 632 and 656. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7wrd
Structure name
mouse trpm8 in lmng in the presence of calcium and icilin
Structure deposition date
2022-01-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
96
Peptide accession
Q8R4D5
Residue number A
632
Residue number B
656
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 632 of Transient receptor potential cation channel subfamily M member 8
Cysteine 656 of Transient receptor potential cation channel subfamily M member 8
8e4n B 587 B 656
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 8 between cysteines 587 and 656. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
8e4n
Structure name
the closed c1-state mouse trpm8 structure in complex with pi(4,5)p2
Structure deposition date
2022-08-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
100
Peptide accession
Q8R4D5
Residue number A
587
Residue number B
656
Peptide name
Transient receptor potential cation channel subfamily M member 8
Ligandability
Cysteine 587 of Transient receptor potential cation channel subfamily M member 8
Cysteine 656 of Transient receptor potential cation channel subfamily M member 8
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