ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Neuronal growth regulator 1

Intramolecular
Cysteine 160 and cysteine 203
Cysteine 60 and cysteine 118
Cysteine 245 and cysteine 297
A redox-regulated disulphide may form within Neuronal growth regulator 1 between cysteines 160 and 203.

Details

Redox score ?
84
PDB code
6dld
Structure name
crystal structure of iglon5/negr1 heterodimer
Structure deposition date
2018-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z3B1
Residue number A
160
Residue number B
203
Peptide name
Neuronal growth regulator 1

Ligandability

Cysteine 160 of Neuronal growth regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Neuronal growth regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuronal growth regulator 1 between cysteines 60 and 118.

Details

Redox score ?
82
PDB code
6u6t
Structure name
neuronal growth regulator 1 (negr1)
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z3B1
Residue number A
60
Residue number B
118
Peptide name
Neuronal growth regulator 1

Ligandability

Cysteine 60 of Neuronal growth regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of Neuronal growth regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuronal growth regulator 1 between cysteines 245 and 297.

Details

Redox score ?
80
PDB code
6u6t
Structure name
neuronal growth regulator 1 (negr1)
Structure deposition date
2019-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z3B1
Residue number A
245
Residue number B
297
Peptide name
Neuronal growth regulator 1

Ligandability

Cysteine 245 of Neuronal growth regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Neuronal growth regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: