ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Autophagy-related protein 9A

Intramolecular
Cysteine 86 and cysteine 122
Cysteine 367 and cysteine 433 L
Cysteine 155 and cysteine 156
A redox-regulated disulphide may form within Autophagy-related protein 9A between cysteines 86 and 122.

Details

Redox score ?
84
PDB code
6wqz
Structure name
structure of human atg9a, the only transmembrane protein of the core autophagy machinery
Structure deposition date
2020-04-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
0
Peptide accession
Q7Z3C6
Residue number A
86
Residue number B
122
Peptide name
Autophagy-related protein 9A

Ligandability

Cysteine 86 of Autophagy-related protein 9A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Autophagy-related protein 9A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Autophagy-related protein 9A between cysteines 367 and 433.

Details

Redox score ?
63
PDB code
6wr4
Structure name
structure of human atg9a, the only transmembrane protein of the core autophagy machinery
Structure deposition date
2020-04-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
41
Peptide accession
Q7Z3C6
Residue number A
367
Residue number B
433
Peptide name
Autophagy-related protein 9A

Ligandability

Cysteine 367 of Autophagy-related protein 9A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 433 of Autophagy-related protein 9A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Autophagy-related protein 9A between cysteines 155 and 156.

Details

Redox score ?
60
PDB code
6wr4
Structure name
structure of human atg9a, the only transmembrane protein of the core autophagy machinery
Structure deposition date
2020-04-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
11
Peptide accession
Q7Z3C6
Residue number A
155
Residue number B
156
Peptide name
Autophagy-related protein 9A

Ligandability

Cysteine 155 of Autophagy-related protein 9A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Autophagy-related protein 9A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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