ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pogo transposable element with ZNF domain

Intramolecular
Cysteine 377 and cysteine 380
Cysteine 377 and cysteine 397
Cysteine 377 and cysteine 398
Cysteine 380 and cysteine 397
Cysteine 397 and cysteine 398
Cysteine 380 and cysteine 398
Cysteine 395 and cysteine 398
Cysteine 395 and cysteine 397
A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 377 and 380.

Details

Redox score ?
91
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide accession
Q7Z3K3
Residue number A
377
Residue number B
380
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 377 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 377 and 397.

Details

Redox score ?
89
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
6
% buried
0
Peptide accession
Q7Z3K3
Residue number A
377
Residue number B
397
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 377 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 377 and 398.

Details

Redox score ?
80
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
0
Peptide accession
Q7Z3K3
Residue number A
377
Residue number B
398
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 377 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 380 and 397.

Details

Redox score ?
80
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
0
Peptide accession
Q7Z3K3
Residue number A
380
Residue number B
397
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 380 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 397 and 398.

Details

Redox score ?
69
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
0
Peptide accession
Q7Z3K3
Residue number A
397
Residue number B
398
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 397 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 380 and 398. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
34
Minimum pKa ?
9
% buried
0
Peptide accession
Q7Z3K3
Residue number A
380
Residue number B
398
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 380 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 395 and 398. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
Q7Z3K3
Residue number A
395
Residue number B
398
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 395 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 398 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pogo transposable element with ZNF domain between cysteines 395 and 397. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2e72
Structure name
solution structure of the zinc finger domain of human kiaa0461
Structure deposition date
2007-01-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide accession
Q7Z3K3
Residue number A
395
Residue number B
397
Peptide name
Pogo transposable element with ZNF domain

Ligandability

Cysteine 395 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Pogo transposable element with ZNF domain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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