Mitochondrial antiviral-signaling protein
Intermolecular
Cysteine 533 of TNF receptor-associated factor 3 and cysteine 140
Cysteine 20 and cysteine 79
Cysteine 136 of Antiviral innate immune response receptor RIG-I and cysteine 13
Cysteine 46 and cysteine 46 L
Cysteine 33 and cysteine 13
Intramolecular
Cysteine 20 and cysteine 46 L
Cysteine 13 and cysteine 20
4ghu A 533 B 140
A redox-regulated disulphide may form between cysteine 533 of TNF receptor-associated factor 3 and cysteine 140 of Mitochondrial antiviral-signaling protein.
Details
Redox score ?
84
PDB code
4ghu
Structure name
crystal structure of traf3/cardif
Structure deposition date
2012-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
TNF receptor-associated factor 3
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
Q60803
Peptide B accession
Q8VCF0
Peptide A residue number
533
Peptide B residue number
140
Ligandability
Cysteine 533 of TNF receptor-associated factor 3
Cysteine 140 of Mitochondrial antiviral-signaling protein
4p4h P 20 M 79
A redox-regulated disulphide may form between two units of Mitochondrial antiviral-signaling protein at cysteines 20 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4p4h
Structure name
caught-in-action signaling complex of rig-i 2card domain and mavs card domain
Structure deposition date
2014-03-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
44
Peptide A name
Mitochondrial antiviral-signaling protein
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
Q7Z434
Peptide B accession
Q7Z434
Peptide A residue number
20
Peptide B residue number
79
Ligandability
Cysteine 20 of Mitochondrial antiviral-signaling protein
Cysteine 79 of Mitochondrial antiviral-signaling protein
4p4h B 136 I 13
A redox-regulated disulphide may form between cysteine 136 of Antiviral innate immune response receptor RIG-I and cysteine 13 of Mitochondrial antiviral-signaling protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4p4h
Structure name
caught-in-action signaling complex of rig-i 2card domain and mavs card domain
Structure deposition date
2014-03-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
97
Peptide A name
Antiviral innate immune response receptor RIG-I
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
O95786
Peptide B accession
Q7Z434
Peptide A residue number
136
Peptide B residue number
13
Ligandability
Cysteine 136 of Antiviral innate immune response receptor RIG-I
Cysteine 13 of Mitochondrial antiviral-signaling protein
2ms7 R 46 S 46
A redox-regulated disulphide may form between two units of Mitochondrial antiviral-signaling protein at cysteines 46 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
2ms7
Structure name
high-resolution solid-state nmr structure of the helical signal transduction filament mavs card
Structure deposition date
2014-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
74
Peptide A name
Mitochondrial antiviral-signaling protein
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
Q7Z434
Peptide B accession
Q7Z434
Peptide A residue number
46
Peptide B residue number
46
Ligandability
2ms7 B 33 M 13
A redox-regulated disulphide may form between two units of Mitochondrial antiviral-signaling protein at cysteines 33 and 13. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
2ms7
Structure name
high-resolution solid-state nmr structure of the helical signal transduction filament mavs card
Structure deposition date
2014-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
72
Peptide A name
Mitochondrial antiviral-signaling protein
Peptide B name
Mitochondrial antiviral-signaling protein
Peptide A accession
Q7Z434
Peptide B accession
Q7Z434
Peptide A residue number
33
Peptide B residue number
13
Ligandability
Cysteine 33 of Mitochondrial antiviral-signaling protein
Cysteine 13 of Mitochondrial antiviral-signaling protein
2ms8 A 20 A 46
A redox-regulated disulphide may form within Mitochondrial antiviral-signaling protein between cysteines 20 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
2ms8
Structure name
solution nmr structure of mavs card
Structure deposition date
2014-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
8
Peptide accession
Q7Z434
Residue number A
20
Residue number B
46
Peptide name
Mitochondrial antiviral-signaling protein
Ligandability
Cysteine 20 of Mitochondrial antiviral-signaling protein
Cysteine 46 of Mitochondrial antiviral-signaling protein
2ms7 K 13 K 20
A redox-regulated disulphide may form within Mitochondrial antiviral-signaling protein between cysteines 13 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
2ms7
Structure name
high-resolution solid-state nmr structure of the helical signal transduction filament mavs card
Structure deposition date
2014-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
64
Peptide accession
Q7Z434
Residue number A
13
Residue number B
20
Peptide name
Mitochondrial antiviral-signaling protein
Ligandability
Cysteine 13 of Mitochondrial antiviral-signaling protein
Cysteine 20 of Mitochondrial antiviral-signaling protein
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