ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein ADM2

Intermolecular
Cysteine 110 and cysteine 299 of Calcitonin gene-related peptide type 1 receptor
Intramolecular
Cysteine 110 and cysteine 115
A redox-regulated disulphide may form between cysteine 110 of Protein ADM2 and cysteine 299 of Calcitonin gene-related peptide type 1 receptor (10 and 299 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6uva
Structure name
cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
Structure deposition date
2019-11-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
nan
Peptide A name
Protein ADM2
Peptide B name
Calcitonin gene-related peptide type 1 receptor
Peptide A accession
Q7Z4H4
Peptide B accession
Q16602
Peptide A residue number
110
Peptide B residue number
299

Ligandability

Cysteine 110 of Protein ADM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Calcitonin gene-related peptide type 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein ADM2 between cysteines 110 and 115 (10 and 15 respectively in this structure).

Details

Redox score ?
86
PDB code
6uva
Structure name
cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
Structure deposition date
2019-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4H4
Residue number A
110
Residue number B
115
Peptide name
Protein ADM2

Ligandability

Cysteine 110 of Protein ADM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Protein ADM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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