HAUS augmin-like complex subunit 6

Intermolecular

Cysteine 43 of HAUS augmin-like complex subunit 2 and cysteine 185

Intramolecular

A redox-regulated disulphide may form between cysteine 43 of HAUS augmin-like complex subunit 2 and cysteine 185 of HAUS augmin-like complex subunit 6.

Details

Redox score ?

PDB code

7sqk

Structure name

cryo-em structure of the human augmin complex

Structure deposition date

2021-11-05

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

HAUS augmin-like complex subunit 2

Peptide B name

HAUS augmin-like complex subunit 6

Peptide A accession

Q9NVX0

Peptide B accession

Q7Z4H7

Peptide A residue number

Peptide B residue number

185

Ligandability

Cysteine 43 of HAUS augmin-like complex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of HAUS augmin-like complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HAUS augmin-like complex subunit 6 between cysteines 165 and 169.

Details

Redox score ?

PDB code

7sqk

Structure name

cryo-em structure of the human augmin complex

Structure deposition date

2021-11-05

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q7Z4H7

Residue number A

165

Residue number B

169

Peptide name

HAUS augmin-like complex subunit 6

Ligandability

Cysteine 165 of HAUS augmin-like complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of HAUS augmin-like complex subunit 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HAUS augmin-like complex subunit 6 between cysteines 93 and 94. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?