ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tetratricopeptide repeat protein 21B

Intramolecular
Cysteine 937 and cysteine 941
Cysteine 792 and cysteine 833
Cysteine 1223 and cysteine 1230
Cysteine 459 and cysteine 477
Cysteine 459 and cysteine 471
Cysteine 1230 and cysteine 1231
Cysteine 887 and cysteine 914
Cysteine 1067 and cysteine 1129
A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 937 and 941.

Details

Redox score ?
75
PDB code
8bbe
Structure name
structure of the ift-a complex; ift-a2 module
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
59
Peptide accession
Q7Z4L5
Residue number A
937
Residue number B
941
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 937 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 941 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 792 and 833.

Details

Redox score ?
73
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
7
% buried
76
Peptide accession
Q7Z4L5
Residue number A
792
Residue number B
833
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 792 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 833 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 1223 and 1230.

Details

Redox score ?
69
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
100
Peptide accession
Q7Z4L5
Residue number A
1223
Residue number B
1230
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 1223 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1230 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 459 and 477.

Details

Redox score ?
68
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
92
Peptide accession
Q7Z4L5
Residue number A
459
Residue number B
477
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 459 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 477 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 459 and 471. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
58
Peptide accession
Q7Z4L5
Residue number A
459
Residue number B
471
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 459 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 1230 and 1231. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
8bbe
Structure name
structure of the ift-a complex; ift-a2 module
Structure deposition date
2022-10-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
96
Peptide accession
Q7Z4L5
Residue number A
1230
Residue number B
1231
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 1230 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1231 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 887 and 914. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
8bbe
Structure name
structure of the ift-a complex; ift-a2 module
Structure deposition date
2022-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
50
Peptide accession
Q7Z4L5
Residue number A
887
Residue number B
914
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 887 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 914 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 21B between cysteines 1067 and 1129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
8bbe
Structure name
structure of the ift-a complex; ift-a2 module
Structure deposition date
2022-10-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
92
Peptide accession
Q7Z4L5
Residue number A
1067
Residue number B
1129
Peptide name
Tetratricopeptide repeat protein 21B

Ligandability

Cysteine 1067 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1129 of Tetratricopeptide repeat protein 21B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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