ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Meiotic recombination protein REC114

Intramolecular
Cysteine 132 and cysteine 133
Cysteine 132 and cysteine 135
Cysteine 102 and cysteine 132
Cysteine 133 and cysteine 135
A redox-regulated disulphide may form within Meiotic recombination protein REC114 between cysteines 132 and 133.

Details

Redox score ?
67
PDB code
6nxf
Structure name
crystal structure of mouse rec114 ph domain in complex with ankrd31 c terminus
Structure deposition date
2019-02-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
36
Peptide accession
Q9CWH4
Residue number A
132
Residue number B
133
Peptide name
Meiotic recombination protein REC114

Ligandability

Cysteine 132 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meiotic recombination protein REC114 between cysteines 132 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7qwv
Structure name
crystal structure of the rec114-topovibl complex
Structure deposition date
2022-01-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
85
Peptide accession
Q9CWH4
Residue number A
132
Residue number B
135
Peptide name
Meiotic recombination protein REC114

Ligandability

Cysteine 132 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meiotic recombination protein REC114 between cysteines 102 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6nxf
Structure name
crystal structure of mouse rec114 ph domain in complex with ankrd31 c terminus
Structure deposition date
2019-02-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
73
Peptide accession
Q9CWH4
Residue number A
102
Residue number B
132
Peptide name
Meiotic recombination protein REC114

Ligandability

Cysteine 102 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meiotic recombination protein REC114 between cysteines 133 and 135. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6hfg
Structure name
structure of the rec114 ph domain
Structure deposition date
2018-08-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
44
Peptide accession
Q9CWH4
Residue number A
133
Residue number B
135
Peptide name
Meiotic recombination protein REC114

Ligandability

Cysteine 133 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 135 of Meiotic recombination protein REC114

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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