Kinesin-like protein KIF21A
Intermolecular
Cysteine 1006 and cysteine 1006
Intramolecular
Cysteine 1421 and cysteine 1437
Cysteine 1352 and cysteine 1369
Cysteine 1588 and cysteine 1603
Cysteine 1352 and cysteine 1633
Cysteine 1497 and cysteine 1588
Cysteine 652 and cysteine 1006
5nfd A 72 B 72
A redox-regulated disulphide may form between two units of Kinesin-like protein KIF21A at cysteines 1006 and 1006 (72 and 72 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5nfd
Structure name
antiparallel monomeric coiled coil of kif21a
Structure deposition date
2017-03-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Kinesin-like protein KIF21A
Peptide B name
Kinesin-like protein KIF21A
Peptide A accession
Q7Z4S6
Peptide B accession
Q7Z4S6
Peptide A residue number
1006
Peptide B residue number
1006
Ligandability
7klj B 1421 B 1437
A redox-regulated disulphide may form within Kinesin-like protein KIF21A between cysteines 1421 and 1437.
Details
Redox score ?
62
PDB code
7klj
Structure name
crystal structure of the wd-repeat domain of human kif21a
Structure deposition date
2020-10-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4S6
Residue number A
1421
Residue number B
1437
Peptide name
Kinesin-like protein KIF21A
Ligandability
Cysteine 1421 of Kinesin-like protein KIF21A
Cysteine 1437 of Kinesin-like protein KIF21A
7klj A 1352 A 1369
A redox-regulated disulphide may form within Kinesin-like protein KIF21A between cysteines 1352 and 1369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7klj
Structure name
crystal structure of the wd-repeat domain of human kif21a
Structure deposition date
2020-10-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4S6
Residue number A
1352
Residue number B
1369
Peptide name
Kinesin-like protein KIF21A
Ligandability
Cysteine 1352 of Kinesin-like protein KIF21A
Cysteine 1369 of Kinesin-like protein KIF21A
7klj B 1588 B 1603
A redox-regulated disulphide may form within Kinesin-like protein KIF21A between cysteines 1588 and 1603. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7klj
Structure name
crystal structure of the wd-repeat domain of human kif21a
Structure deposition date
2020-10-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4S6
Residue number A
1588
Residue number B
1603
Peptide name
Kinesin-like protein KIF21A
Ligandability
Cysteine 1588 of Kinesin-like protein KIF21A
Cysteine 1603 of Kinesin-like protein KIF21A
7klj A 1352 A 1633
A redox-regulated disulphide may form within Kinesin-like protein KIF21A between cysteines 1352 and 1633. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
7klj
Structure name
crystal structure of the wd-repeat domain of human kif21a
Structure deposition date
2020-10-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4S6
Residue number A
1352
Residue number B
1633
Peptide name
Kinesin-like protein KIF21A
Ligandability
Cysteine 1352 of Kinesin-like protein KIF21A
Cysteine 1633 of Kinesin-like protein KIF21A
7klj B 1497 B 1588
A redox-regulated disulphide may form within Kinesin-like protein KIF21A between cysteines 1497 and 1588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
7klj
Structure name
crystal structure of the wd-repeat domain of human kif21a
Structure deposition date
2020-10-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4S6
Residue number A
1497
Residue number B
1588
Peptide name
Kinesin-like protein KIF21A
Ligandability
Cysteine 1497 of Kinesin-like protein KIF21A
Cysteine 1588 of Kinesin-like protein KIF21A
5nfd A 13 A 72
A redox-regulated disulphide may form within Kinesin-like protein KIF21A between cysteines 652 and 1006 (13 and 72 respectively in this structure).
Details
Redox score ?
nan
PDB code
5nfd
Structure name
antiparallel monomeric coiled coil of kif21a
Structure deposition date
2017-03-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z4S6
Residue number A
652
Residue number B
1006
Peptide name
Kinesin-like protein KIF21A
Ligandability
Cysteine 652 of Kinesin-like protein KIF21A
Cysteine 1006 of Kinesin-like protein KIF21A
Uncertain whether structure cysteine 13 has been assigned to correct residue.
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