ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Wings apart-like protein homolog

Intramolecular
Cysteine 675 and cysteine 719
Cysteine 891 and cysteine 929
Cysteine 1133 and cysteine 1190
Cysteine 831 and cysteine 854
Cysteine 891 and cysteine 964
Cysteine 831 and cysteine 929
Cysteine 1131 and cysteine 1133
A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 675 and 719.

Details

Redox score ?
70
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
7
% buried
74
Peptide accession
Q7Z5K2
Residue number A
675
Residue number B
719
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 675 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 719 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 891 and 929.

Details

Redox score ?
67
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide accession
Q7Z5K2
Residue number A
891
Residue number B
929
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 891 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 929 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 1133 and 1190.

Details

Redox score ?
63
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
52
Peptide accession
Q7Z5K2
Residue number A
1133
Residue number B
1190
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 1133 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1190 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 831 and 854. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
93
Peptide accession
Q7Z5K2
Residue number A
831
Residue number B
854
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 831 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 854 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 891 and 964. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
Q7Z5K2
Residue number A
891
Residue number B
964
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 891 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 964 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 831 and 929. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
94
Peptide accession
Q7Z5K2
Residue number A
831
Residue number B
929
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 831 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 929 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Wings apart-like protein homolog between cysteines 1131 and 1133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4k6j
Structure name
human cohesin inhibitor wapl
Structure deposition date
2013-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
81
Peptide accession
Q7Z5K2
Residue number A
1131
Residue number B
1133
Peptide name
Wings apart-like protein homolog

Ligandability

Cysteine 1131 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1133 of Wings apart-like protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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