ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Protein sidekick-1

Intramolecular
Cysteine 483 and cysteine 535
Cysteine 108 and cysteine 151
Cysteine 297 and cysteine 344
Cysteine 390 and cysteine 440
A redox-regulated disulphide may form within Protein sidekick-1 between cysteines 483 and 535 (403 and 455 respectively in this structure).

Details

Redox score ?
83
PDB code
5k6w
Structure name
sidekick-1 immunoglobulin domains 1-5
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3UH53
Residue number A
483
Residue number B
535
Peptide name
Protein sidekick-1

Ligandability

Cysteine 483 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 535 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein sidekick-1 between cysteines 108 and 151 (28 and 71 respectively in this structure).

Details

Redox score ?
81
PDB code
5k6w
Structure name
sidekick-1 immunoglobulin domains 1-5
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3UH53
Residue number A
108
Residue number B
151
Peptide name
Protein sidekick-1

Ligandability

Cysteine 108 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein sidekick-1 between cysteines 297 and 344 (217 and 264 respectively in this structure).

Details

Redox score ?
81
PDB code
5k6z
Structure name
sidekick chimera containing sidekick-2 immunoglobulin domains 1-2 and sidekick-1 immunoglobulin domains 3-4
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3UH53
Residue number A
297
Residue number B
344
Peptide name
Protein sidekick-1

Ligandability

Cysteine 297 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein sidekick-1 between cysteines 390 and 440 (310 and 360 respectively in this structure).

Details

Redox score ?
80
PDB code
5k6w
Structure name
sidekick-1 immunoglobulin domains 1-5
Structure deposition date
2016-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3UH53
Residue number A
390
Residue number B
440
Peptide name
Protein sidekick-1

Ligandability

Cysteine 390 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 440 of Protein sidekick-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: