Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Intermolecular
Cysteine 358 and cysteine 358
Intramolecular
Cysteine 216 and cysteine 218
Cysteine 384 and cysteine 403
Cysteine 403 and cysteine 404
Cysteine 373 and cysteine 403
Cysteine 384 and cysteine 404
3tca A 358 B 358
A redox-regulated disulphide may form between two units of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein at cysteines 358 and 358. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3tca
Structure name
crystal structure of the ras-associating and pleckstrin-homology domains of riam
Structure deposition date
2011-08-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
51
Peptide A name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Peptide B name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Peptide A accession
Q8R5A3
Peptide B accession
Q8R5A3
Peptide A residue number
358
Peptide B residue number
358
Ligandability
4kvg B 216 B 218
A redox-regulated disulphide may form within Amyloid beta A4 precursor protein-binding family B member 1-interacting protein between cysteines 216 and 218.
Details
Redox score ?
75
PDB code
4kvg
Structure name
crystal structure of riam ra-ph domains in complex with gtp bound rap1
Structure deposition date
2013-05-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
23
Peptide accession
Q8R5A3
Residue number A
216
Residue number B
218
Peptide name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Ligandability
Cysteine 216 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Cysteine 218 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
6olu A 384 A 403
A redox-regulated disulphide may form within Amyloid beta A4 precursor protein-binding family B member 1-interacting protein between cysteines 384 and 403.
Details
Redox score ?
74
PDB code
6olu
Structure name
riam ra-ph core structure in the p212121 space group
Structure deposition date
2019-04-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
6
% buried
61
Peptide accession
Q8R5A3
Residue number A
384
Residue number B
403
Peptide name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Ligandability
Cysteine 384 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Cysteine 403 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
4kvg D 403 D 404
A redox-regulated disulphide may form within Amyloid beta A4 precursor protein-binding family B member 1-interacting protein between cysteines 403 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4kvg
Structure name
crystal structure of riam ra-ph domains in complex with gtp bound rap1
Structure deposition date
2013-05-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
66
Peptide accession
Q8R5A3
Residue number A
403
Residue number B
404
Peptide name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Ligandability
Cysteine 403 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Cysteine 404 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
4kvg D 373 D 403
A redox-regulated disulphide may form within Amyloid beta A4 precursor protein-binding family B member 1-interacting protein between cysteines 373 and 403. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4kvg
Structure name
crystal structure of riam ra-ph domains in complex with gtp bound rap1
Structure deposition date
2013-05-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
8
% buried
62
Peptide accession
Q8R5A3
Residue number A
373
Residue number B
403
Peptide name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Ligandability
Cysteine 373 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Cysteine 403 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
6olu A 384 A 404
A redox-regulated disulphide may form within Amyloid beta A4 precursor protein-binding family B member 1-interacting protein between cysteines 384 and 404. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6olu
Structure name
riam ra-ph core structure in the p212121 space group
Structure deposition date
2019-04-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
76
Peptide accession
Q8R5A3
Residue number A
384
Residue number B
404
Peptide name
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Ligandability
Cysteine 384 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Cysteine 404 of Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
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