a tool for identifying drug-targetable redox-active disulphides

Neuroepithelial cell-transforming gene 1 protein

Intramolecular

Cysteine 389 and cysteine 495

A redox-regulated disulphide may form within Neuroepithelial cell-transforming gene 1 protein between cysteines 389 and 495.

Details

Redox score ?

69

PDB code

Structure name

crystal structure of human rhoa in complex with dh/ph fragment of the guanine nucleotide exchange factor net1

Structure deposition date

2015-01-05

Thiol separation (Å)

4

Half-sphere exposure sum ?

69

Minimum pK_a ?

8

% buried

98

Peptide accession

Residue number A

389

Residue number B

495

Peptide name

Neuroepithelial cell-transforming gene 1 protein

Ligandability

Cysteine 389 of Neuroepithelial cell-transforming gene 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 495 of Neuroepithelial cell-transforming gene 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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