ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

B- and T-lymphocyte attenuator

Intramolecular
Cysteine 34 and cysteine 63
Cysteine 72 and cysteine 79
Cysteine 58 and cysteine 115
Cysteine 72 and cysteine 115
Cysteine 79 and cysteine 115
Cysteine 58 and cysteine 72
A redox-regulated disulphide may form within B- and T-lymphocyte attenuator between cysteines 34 and 63.

Details

Redox score ?
90
PDB code
2aw2
Structure name
crystal structure of the human btla-hvem complex
Structure deposition date
2005-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z6A9
Residue number A
34
Residue number B
63
Peptide name
B- and T-lymphocyte attenuator

Ligandability

Cysteine 34 of B- and T-lymphocyte attenuator

Cysteine 63 of B- and T-lymphocyte attenuator

A redox-regulated disulphide may form within B- and T-lymphocyte attenuator between cysteines 72 and 79.

Details

Redox score ?
85
PDB code
6nyp
Structure name
crystal structure of ul144/btla complex
Structure deposition date
2019-02-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z6A9
Residue number A
72
Residue number B
79
Peptide name
B- and T-lymphocyte attenuator

Ligandability

Cysteine 72 of B- and T-lymphocyte attenuator

Cysteine 79 of B- and T-lymphocyte attenuator

A redox-regulated disulphide may form within B- and T-lymphocyte attenuator between cysteines 58 and 115.

Details

Redox score ?
79
PDB code
2aw2
Structure name
crystal structure of the human btla-hvem complex
Structure deposition date
2005-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z6A9
Residue number A
58
Residue number B
115
Peptide name
B- and T-lymphocyte attenuator

Ligandability

Cysteine 58 of B- and T-lymphocyte attenuator

Cysteine 115 of B- and T-lymphocyte attenuator

A redox-regulated disulphide may form within B- and T-lymphocyte attenuator between cysteines 72 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6nyp
Structure name
crystal structure of ul144/btla complex
Structure deposition date
2019-02-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z6A9
Residue number A
72
Residue number B
115
Peptide name
B- and T-lymphocyte attenuator

Ligandability

Cysteine 72 of B- and T-lymphocyte attenuator

Cysteine 115 of B- and T-lymphocyte attenuator

A redox-regulated disulphide may form within B- and T-lymphocyte attenuator between cysteines 79 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6nyp
Structure name
crystal structure of ul144/btla complex
Structure deposition date
2019-02-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z6A9
Residue number A
79
Residue number B
115
Peptide name
B- and T-lymphocyte attenuator

Ligandability

Cysteine 79 of B- and T-lymphocyte attenuator

Cysteine 115 of B- and T-lymphocyte attenuator

A redox-regulated disulphide may form within B- and T-lymphocyte attenuator between cysteines 58 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6nyp
Structure name
crystal structure of ul144/btla complex
Structure deposition date
2019-02-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q7Z6A9
Residue number A
58
Residue number B
72
Peptide name
B- and T-lymphocyte attenuator

Ligandability

Cysteine 58 of B- and T-lymphocyte attenuator

Cysteine 72 of B- and T-lymphocyte attenuator

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