ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Intramolecular
Cysteine 1085 and cysteine 1092
Cysteine 1135 and cysteine 1160
Cysteine 1085 and cysteine 1160
A redox-regulated disulphide may form within Ankyrin repeat and sterile alpha motif domain-containing protein 1B between cysteines 1085 and 1092 (44 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2m38
Structure name
ptb domain of aida1
Structure deposition date
2013-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
28
Peptide accession
Q7Z6G8
Residue number A
1085
Residue number B
1092
Peptide name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Ligandability

Cysteine 1085 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1092 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ankyrin repeat and sterile alpha motif domain-containing protein 1B between cysteines 1135 and 1160 (94 and 119 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2m38
Structure name
ptb domain of aida1
Structure deposition date
2013-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
48
Peptide accession
Q7Z6G8
Residue number A
1135
Residue number B
1160
Peptide name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Ligandability

Cysteine 1135 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1160 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ankyrin repeat and sterile alpha motif domain-containing protein 1B between cysteines 1085 and 1160 (44 and 119 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2m38
Structure name
ptb domain of aida1
Structure deposition date
2013-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
55
Peptide accession
Q7Z6G8
Residue number A
1085
Residue number B
1160
Peptide name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Ligandability

Cysteine 1085 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1160 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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