ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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tRNA-specific adenosine deaminase 2

Intramolecular
Cysteine 134 and cysteine 154
Cysteine 107 and cysteine 110
Cysteine 46 and cysteine 110
Cysteine 107 and cysteine 134
Cysteine 110 and cysteine 134
A redox-regulated disulphide may form within tRNA-specific adenosine deaminase 2 between cysteines 134 and 154.

Details

Redox score ?
78
PDB code
3dh1
Structure name
crystal structure of human trna-specific adenosine-34 deaminase subunit adat2
Structure deposition date
2008-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
64
Peptide accession
Q7Z6V5
Residue number A
134
Residue number B
154
Peptide name
tRNA-specific adenosine deaminase 2

Ligandability

Cysteine 134 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA-specific adenosine deaminase 2 between cysteines 107 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7nz7
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex 1
Structure deposition date
2021-03-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
17
% buried
nan
Peptide accession
Q6P6J0
Residue number A
107
Residue number B
110
Peptide name
tRNA-specific adenosine deaminase 2

Ligandability

Cysteine 107 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA-specific adenosine deaminase 2 between cysteines 46 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7nz7
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex 1
Structure deposition date
2021-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
Q6P6J0
Residue number A
46
Residue number B
110
Peptide name
tRNA-specific adenosine deaminase 2

Ligandability

Cysteine 46 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA-specific adenosine deaminase 2 between cysteines 107 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7nz8
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex 2
Structure deposition date
2021-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
18
% buried
nan
Peptide accession
Q6P6J0
Residue number A
107
Residue number B
134
Peptide name
tRNA-specific adenosine deaminase 2

Ligandability

Cysteine 107 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA-specific adenosine deaminase 2 between cysteines 110 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
18
PDB code
7nz8
Structure name
crystal structure of mouse adat2/adat3 trna deamination complex 2
Structure deposition date
2021-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
17
% buried
93
Peptide accession
Q6P6J0
Residue number A
110
Residue number B
134
Peptide name
tRNA-specific adenosine deaminase 2

Ligandability

Cysteine 110 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of tRNA-specific adenosine deaminase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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