ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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39S ribosomal protein L10, mitochondrial

Intermolecular
Cysteine 64 and cysteine 70 of 39S ribosomal protein S18a, mitochondrial
Cysteine 64 and cysteine 73 of 39S ribosomal protein S18a, mitochondrial
Cysteine 64 and cysteine 108 of 39S ribosomal protein S18a, mitochondrial
A redox-regulated disulphide may form between cysteine 64 of 39S ribosomal protein L10, mitochondrial and cysteine 70 of 39S ribosomal protein S18a, mitochondrial.

Details

Redox score ?
82
PDB code
7oi7
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 2
Structure deposition date
2021-05-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
44
Peptide A name
39S ribosomal protein L10, mitochondrial
Peptide B name
39S ribosomal protein S18a, mitochondrial
Peptide A accession
Q7Z7H8
Peptide B accession
Q9NVS2
Peptide A residue number
64
Peptide B residue number
70

Ligandability

Cysteine 64 of 39S ribosomal protein L10, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of 39S ribosomal protein S18a, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 64 of 39S ribosomal protein L10, mitochondrial and cysteine 73 of 39S ribosomal protein S18a, mitochondrial.

Details

Redox score ?
82
PDB code
7of0
Structure name
structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with mterf4-nsun4 (dataset1)
Structure deposition date
2021-05-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
38
Peptide A name
39S ribosomal protein L10, mitochondrial
Peptide B name
39S ribosomal protein S18a, mitochondrial
Peptide A accession
Q7Z7H8
Peptide B accession
Q9NVS2
Peptide A residue number
64
Peptide B residue number
73

Ligandability

Cysteine 64 of 39S ribosomal protein L10, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of 39S ribosomal protein S18a, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 64 of 39S ribosomal protein L10, mitochondrial and cysteine 108 of 39S ribosomal protein S18a, mitochondrial.

Details

Redox score ?
80
PDB code
7oie
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 5b
Structure deposition date
2021-05-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
53
Minimum pKa ?
11
% buried
nan
Peptide A name
39S ribosomal protein L10, mitochondrial
Peptide B name
39S ribosomal protein S18a, mitochondrial
Peptide A accession
Q7Z7H8
Peptide B accession
Q9NVS2
Peptide A residue number
64
Peptide B residue number
108

Ligandability

Cysteine 64 of 39S ribosomal protein L10, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of 39S ribosomal protein S18a, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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