ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein zer-1 homolog

Intramolecular
Cysteine 718 and cysteine 754
Cysteine 540 and cysteine 577
A redox-regulated disulphide may form within Protein zer-1 homolog between cysteines 718 and 754.

Details

Redox score ?
72
PDB code
7ep3
Structure name
crystal structure of zer1 bound to gagn degron
Structure deposition date
2021-04-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
47
Peptide accession
Q7Z7L7
Residue number A
718
Residue number B
754
Peptide name
Protein zer-1 homolog

Ligandability

Cysteine 718 of Protein zer-1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 754 of Protein zer-1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein zer-1 homolog between cysteines 540 and 577. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7ep5
Structure name
crystal structure of zer1 bound to gklh degron
Structure deposition date
2021-04-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
62
Peptide accession
Q7Z7L7
Residue number A
540
Residue number B
577
Peptide name
Protein zer-1 homolog

Ligandability

Cysteine 540 of Protein zer-1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 577 of Protein zer-1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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