ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

Intermolecular
Cysteine 219 of If kappa light chain and cysteine 128
Intramolecular
Cysteine 22 and cysteine 97
Cysteine 22 and cysteine 22
A redox-regulated disulphide may form between cysteine 219 of If kappa light chain and cysteine 128 of Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region (213 and 128 respectively in this structure).

Details

Redox score ?
nan
PDB code
2iqa
Structure name
pfa2 fab fragment, monoclinic apo form
Structure deposition date
2006-10-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
13
Peptide A name
If kappa light chain
Peptide B name
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region
Peptide A accession
A2NHM3
Peptide B accession
Q811U5
Peptide A residue number
219
Peptide B residue number
128

Ligandability

Cysteine 219 of If kappa light chain

Cysteine 128 of Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

Cysteine 128 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region between cysteines 22 and 97 (22 and 92 respectively in this structure).

Details

Redox score ?
81
PDB code
2iqa
Structure name
pfa2 fab fragment, monoclinic apo form
Structure deposition date
2006-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q811U5
Residue number A
22
Residue number B
97
Peptide name
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

Ligandability

Cysteine 22 of Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

Cysteine 97 of Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

A redox-regulated disulphide may form within Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region between cysteines 22 and 22 (140 and 195 respectively in this structure).

Details

Redox score ?
78
PDB code
2iqa
Structure name
pfa2 fab fragment, monoclinic apo form
Structure deposition date
2006-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q811U5
Residue number A
22
Residue number B
22
Peptide name
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

Ligandability

Cysteine 22 of Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

Cysteine 22 of Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region

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