ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

N-acetylgalactosaminyltransferase 7

Intramolecular
Cysteine 426 and cysteine 507
Cysteine 585 and cysteine 600
Cysteine 625 and cysteine 640
Cysteine 545 and cysteine 562
Cysteine 197 and cysteine 435
A redox-regulated disulphide may form within N-acetylgalactosaminyltransferase 7 between cysteines 426 and 507.

Details

Redox score ?
85
PDB code
6iwr
Structure name
crystal structure of galnac-t7 with udp, galnac and mn2+
Structure deposition date
2018-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SF2
Residue number A
426
Residue number B
507
Peptide name
N-acetylgalactosaminyltransferase 7

Ligandability

Cysteine 426 of N-acetylgalactosaminyltransferase 7

Cysteine 507 of N-acetylgalactosaminyltransferase 7

A redox-regulated disulphide may form within N-acetylgalactosaminyltransferase 7 between cysteines 585 and 600.

Details

Redox score ?
84
PDB code
6iwr
Structure name
crystal structure of galnac-t7 with udp, galnac and mn2+
Structure deposition date
2018-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SF2
Residue number A
585
Residue number B
600
Peptide name
N-acetylgalactosaminyltransferase 7

Ligandability

Cysteine 585 of N-acetylgalactosaminyltransferase 7

Cysteine 600 of N-acetylgalactosaminyltransferase 7

A redox-regulated disulphide may form within N-acetylgalactosaminyltransferase 7 between cysteines 625 and 640.

Details

Redox score ?
83
PDB code
6iwr
Structure name
crystal structure of galnac-t7 with udp, galnac and mn2+
Structure deposition date
2018-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SF2
Residue number A
625
Residue number B
640
Peptide name
N-acetylgalactosaminyltransferase 7

Ligandability

Cysteine 625 of N-acetylgalactosaminyltransferase 7

Cysteine 640 of N-acetylgalactosaminyltransferase 7

A redox-regulated disulphide may form within N-acetylgalactosaminyltransferase 7 between cysteines 545 and 562.

Details

Redox score ?
82
PDB code
6iwr
Structure name
crystal structure of galnac-t7 with udp, galnac and mn2+
Structure deposition date
2018-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SF2
Residue number A
545
Residue number B
562
Peptide name
N-acetylgalactosaminyltransferase 7

Ligandability

Cysteine 545 of N-acetylgalactosaminyltransferase 7

Cysteine 562 of N-acetylgalactosaminyltransferase 7

A redox-regulated disulphide may form within N-acetylgalactosaminyltransferase 7 between cysteines 197 and 435.

Details

Redox score ?
80
PDB code
6iwq
Structure name
crystal structure of galnac-t7 with mn2+
Structure deposition date
2018-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SF2
Residue number A
197
Residue number B
435
Peptide name
N-acetylgalactosaminyltransferase 7

Ligandability

Cysteine 197 of N-acetylgalactosaminyltransferase 7

Cysteine 435 of N-acetylgalactosaminyltransferase 7

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