ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Intermolecular
Cysteine 191 and cysteine 208 of Dehydrodolichyl diphosphate synthase complex subunit NUS1
Intramolecular
Cysteine 117 and cysteine 148
A redox-regulated disulphide may form between cysteine 191 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS and cysteine 208 of Dehydrodolichyl diphosphate synthase complex subunit NUS1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6z1n
Structure name
structure of the human heterotetrameric cis-prenyltransferase complex
Structure deposition date
2020-05-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
93
Peptide A name
Dehydrodolichyl diphosphate synthase complex subunit DHDDS
Peptide B name
Dehydrodolichyl diphosphate synthase complex subunit NUS1
Peptide A accession
Q86SQ9
Peptide B accession
Q96E22
Peptide A residue number
191
Peptide B residue number
208

Ligandability

Cysteine 191 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Dehydrodolichyl diphosphate synthase complex subunit NUS1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dehydrodolichyl diphosphate synthase complex subunit DHDDS between cysteines 117 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7pay
Structure name
structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and ggspp
Structure deposition date
2021-07-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
51
Peptide accession
Q86SQ9
Residue number A
117
Residue number B
148
Peptide name
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Ligandability

Cysteine 117 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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