ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polypeptide N-acetylgalactosaminyltransferase 10

Intramolecular
Cysteine 356 and cysteine 432
Cysteine 523 and cysteine 538
Cysteine 135 and cysteine 365
Cysteine 471 and cysteine 488
Cysteine 563 and cysteine 578
A redox-regulated disulphide may form within Polypeptide N-acetylgalactosaminyltransferase 10 between cysteines 356 and 432.

Details

Redox score ?
86
PDB code
2d7r
Structure name
crystal structure of pp-galnac-t10 complexed with galnac-ser on lectin domain
Structure deposition date
2005-11-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SR1
Residue number A
356
Residue number B
432
Peptide name
Polypeptide N-acetylgalactosaminyltransferase 10

Ligandability

Cysteine 356 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 432 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polypeptide N-acetylgalactosaminyltransferase 10 between cysteines 523 and 538.

Details

Redox score ?
85
PDB code
2d7i
Structure name
crystal structure of pp-galnac-t10 with udp, galnac and mn2+
Structure deposition date
2005-11-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SR1
Residue number A
523
Residue number B
538
Peptide name
Polypeptide N-acetylgalactosaminyltransferase 10

Ligandability

Cysteine 523 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 538 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polypeptide N-acetylgalactosaminyltransferase 10 between cysteines 135 and 365.

Details

Redox score ?
83
PDB code
2d7i
Structure name
crystal structure of pp-galnac-t10 with udp, galnac and mn2+
Structure deposition date
2005-11-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SR1
Residue number A
135
Residue number B
365
Peptide name
Polypeptide N-acetylgalactosaminyltransferase 10

Ligandability

Cysteine 135 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polypeptide N-acetylgalactosaminyltransferase 10 between cysteines 471 and 488.

Details

Redox score ?
82
PDB code
2d7i
Structure name
crystal structure of pp-galnac-t10 with udp, galnac and mn2+
Structure deposition date
2005-11-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SR1
Residue number A
471
Residue number B
488
Peptide name
Polypeptide N-acetylgalactosaminyltransferase 10

Ligandability

Cysteine 471 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 488 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polypeptide N-acetylgalactosaminyltransferase 10 between cysteines 563 and 578.

Details

Redox score ?
82
PDB code
2d7r
Structure name
crystal structure of pp-galnac-t10 complexed with galnac-ser on lectin domain
Structure deposition date
2005-11-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86SR1
Residue number A
563
Residue number B
578
Peptide name
Polypeptide N-acetylgalactosaminyltransferase 10

Ligandability

Cysteine 563 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Polypeptide N-acetylgalactosaminyltransferase 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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