ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcriptional regulator Kaiso

Intramolecular
Cysteine 524 and cysteine 527
Cysteine 552 and cysteine 555
Cysteine 496 and cysteine 499
A redox-regulated disulphide may form within Transcriptional regulator Kaiso between cysteines 524 and 527.

Details

Redox score ?
86
PDB code
5vmz
Structure name
kaiso (zbtb33) e535q mutant zinc finger dna binding domain in complex with a double cpg-methylated dna resembling the specific kaiso binding sequence (kbs)
Structure deposition date
2017-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
Q86T24
Residue number A
524
Residue number B
527
Peptide name
Transcriptional regulator Kaiso

Ligandability

Cysteine 524 of Transcriptional regulator Kaiso

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of Transcriptional regulator Kaiso

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional regulator Kaiso between cysteines 552 and 555.

Details

Redox score ?
82
PDB code
5vmz
Structure name
kaiso (zbtb33) e535q mutant zinc finger dna binding domain in complex with a double cpg-methylated dna resembling the specific kaiso binding sequence (kbs)
Structure deposition date
2017-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
5
Peptide accession
Q86T24
Residue number A
552
Residue number B
555
Peptide name
Transcriptional regulator Kaiso

Ligandability

Cysteine 552 of Transcriptional regulator Kaiso

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 555 of Transcriptional regulator Kaiso

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional regulator Kaiso between cysteines 496 and 499.

Details

Redox score ?
80
PDB code
5vmv
Structure name
kaiso (zbtb33) zinc finger dna binding domain in complex with its double cpg-methylated dna consensus binding site
Structure deposition date
2017-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
20
Peptide accession
Q86T24
Residue number A
496
Residue number B
499
Peptide name
Transcriptional regulator Kaiso

Ligandability

Cysteine 496 of Transcriptional regulator Kaiso

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of Transcriptional regulator Kaiso

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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