ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tetratricopeptide repeat protein 7B

Intermolecular
Cysteine 1611 of Phosphatidylinositol 4-kinase alpha and cysteine 423
Intramolecular
Cysteine 606 and cysteine 718
Cysteine 17 and cysteine 21
Cysteine 151 and cysteine 175
A redox-regulated disulphide may form between cysteine 1611 of Phosphatidylinositol 4-kinase alpha and cysteine 423 of Tetratricopeptide repeat protein 7B. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6bq1
Structure name
human pi4kiiia lipid kinase complex
Structure deposition date
2017-11-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
96
Peptide A name
Phosphatidylinositol 4-kinase alpha
Peptide B name
Tetratricopeptide repeat protein 7B
Peptide A accession
P42356
Peptide B accession
Q86TV6
Peptide A residue number
1611
Peptide B residue number
423

Ligandability

Cysteine 1611 of Phosphatidylinositol 4-kinase alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 7B between cysteines 606 and 718. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5dse
Structure name
crystal structure of the ttc7b/hyccin complex
Structure deposition date
2015-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
66
Peptide accession
Q86TV6
Residue number A
606
Residue number B
718
Peptide name
Tetratricopeptide repeat protein 7B

Ligandability

Cysteine 606 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 718 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 7B between cysteines 17 and 21. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5dse
Structure name
crystal structure of the ttc7b/hyccin complex
Structure deposition date
2015-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
58
Peptide accession
Q86TV6
Residue number A
17
Residue number B
21
Peptide name
Tetratricopeptide repeat protein 7B

Ligandability

Cysteine 17 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 21 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetratricopeptide repeat protein 7B between cysteines 151 and 175. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
5dse
Structure name
crystal structure of the ttc7b/hyccin complex
Structure deposition date
2015-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
84
Peptide accession
Q86TV6
Residue number A
151
Residue number B
175
Peptide name
Tetratricopeptide repeat protein 7B

Ligandability

Cysteine 151 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Tetratricopeptide repeat protein 7B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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