N6-adenosine-methyltransferase catalytic subunit

Intermolecular

Cysteine 500 and cysteine 120 of N6-adenosine-methyltransferase non-catalytic subunit L

Intramolecular

A redox-regulated disulphide may form between cysteine 500 of N6-adenosine-methyltransferase catalytic subunit and cysteine 120 of N6-adenosine-methyltransferase non-catalytic subunit. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7o0q

Structure name

crystal structure of the human mettl3-mettl14 complex bound to compound 12 (ado_ad_066)

Structure deposition date

2021-03-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

N6-adenosine-methyltransferase catalytic subunit

Peptide B name

N6-adenosine-methyltransferase non-catalytic subunit

Peptide A accession

Q86U44

Peptide B accession

Q9HCE5

Peptide A residue number

500

Peptide B residue number

120

Ligandability

Cysteine 500 of N6-adenosine-methyltransferase catalytic subunit

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of N6-adenosine-methyltransferase non-catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N6-adenosine-methyltransferase catalytic subunit between cysteines 375 and 376. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?