ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

LIM domain-binding protein 1

Intramolecular
Cysteine 5 and cysteine 7
Cysteine 109 and cysteine 7
Cysteine 10 and cysteine 7
Cysteine 109 and cysteine 233
Cysteine 269 and cysteine 273
Cysteine 10 and cysteine 53
Cysteine 10 and cysteine 58
Cysteine 109 and cysteine 10
Cysteine 7 and cysteine 42
Cysteine 7 and cysteine 85
More...
Cysteine 5 and cysteine 10
Cysteine 7 and cysteine 104
Cysteine 273 and cysteine 67
Cysteine 87 and cysteine 159
Cysteine 33 and cysteine 269
Cysteine 90 and cysteine 159
Cysteine 38 and cysteine 269
Cysteine 45 and cysteine 273
Cysteine 115 and cysteine 118
Cysteine 33 and cysteine 36
Cysteine 48 and cysteine 67
Cysteine 94 and cysteine 269
Cysteine 36 and cysteine 269
Cysteine 94 and cysteine 97
Cysteine 38 and cysteine 58
Cysteine 122 and cysteine 144
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 5 and 7 (23 and 47 respectively in this structure).

Details

Redox score ?
85
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
13
Peptide accession
P70662
Residue number A
5
Residue number B
7
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 5 of LIM domain-binding protein 1

Cysteine 7 of LIM domain-binding protein 1

Uncertain whether structure cysteine 23 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 109 and 7 (8 and 32 respectively in this structure).

Details

Redox score ?
82
PDB code
1m3v
Structure name
flin4: fusion of the lim binding domain of ldb1 and the n-terminal lim domain of lmo4
Structure deposition date
2002-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
20
Peptide accession
P70662
Residue number A
109
Residue number B
7
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 109 of LIM domain-binding protein 1

Cysteine 7 of LIM domain-binding protein 1

A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 10 and 7 (26 and 47 respectively in this structure).

Details

Redox score ?
77
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
4
Peptide accession
P70662
Residue number A
10
Residue number B
7
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 10 of LIM domain-binding protein 1

Cysteine 7 of LIM domain-binding protein 1

A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 109 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6tyd
Structure name
structure of human ldb1 in complex with ssbp2
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
23
Peptide accession
Q86U70
Residue number A
109
Residue number B
233
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 109 of LIM domain-binding protein 1

Cysteine 233 of LIM domain-binding protein 1

A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 269 and 273. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6tyd
Structure name
structure of human ldb1 in complex with ssbp2
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
44
Peptide accession
Q86U70
Residue number A
269
Residue number B
273
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 269 of LIM domain-binding protein 1

Cysteine 273 of LIM domain-binding protein 1

A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 10 and 53 (50 and 53 respectively in this structure).

Details

Redox score ?
nan
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
10
Peptide accession
P70662
Residue number A
10
Residue number B
53
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 10 of LIM domain-binding protein 1

Cysteine 53 of LIM domain-binding protein 1

Cysteine 53 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 10 and 58 (35 and 58 respectively in this structure).

Details

Redox score ?
nan
PDB code
1m3v
Structure name
flin4: fusion of the lim binding domain of ldb1 and the n-terminal lim domain of lmo4
Structure deposition date
2002-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
28
Peptide accession
P70662
Residue number A
10
Residue number B
58
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 10 of LIM domain-binding protein 1

Cysteine 58 of LIM domain-binding protein 1

Cysteine 58 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 109 and 10 (17 and 20 respectively in this structure).

Details

Redox score ?
nan
PDB code
4jcj
Structure name
crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Structure deposition date
2013-02-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
6
% buried
4
Peptide accession
P70662
Residue number A
109
Residue number B
10
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 109 of LIM domain-binding protein 1

Cysteine 10 of LIM domain-binding protein 1

Uncertain whether structure cysteine 20 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 7 and 42 (17 and 42 respectively in this structure).

Details

Redox score ?
nan
PDB code
4jcj
Structure name
crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Structure deposition date
2013-02-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
5
% buried
4
Peptide accession
P70662
Residue number A
7
Residue number B
42
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 7 of LIM domain-binding protein 1

Cysteine 42 of LIM domain-binding protein 1

Cysteine 42 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 7 and 85 (6 and 30 respectively in this structure).

Details

Redox score ?
nan
PDB code
1j2o
Structure name
structure of flin2, a complex containing the n-terminal lim domain of lmo2 and ldb1-lid
Structure deposition date
2003-01-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
23
Peptide accession
P70662
Residue number A
7
Residue number B
85
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 7 of LIM domain-binding protein 1

Cysteine 85 of LIM domain-binding protein 1

Uncertain whether structure cysteine 6 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 5 and 10 (23 and 26 respectively in this structure).

Details

Redox score ?
nan
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
5
% buried
9
Peptide accession
P70662
Residue number A
5
Residue number B
10
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 5 of LIM domain-binding protein 1

Cysteine 10 of LIM domain-binding protein 1

Uncertain whether structure cysteine 23 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 7 and 104 (79 and 104 respectively in this structure).

Details

Redox score ?
nan
PDB code
4jcj
Structure name
crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Structure deposition date
2013-02-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
5
% buried
8
Peptide accession
P70662
Residue number A
7
Residue number B
104
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 7 of LIM domain-binding protein 1

Cysteine 104 of LIM domain-binding protein 1

Uncertain whether structure cysteine 79 has been assigned to correct residue.
Cysteine 104 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 273 and 67 (58 and 67 respectively in this structure).

Details

Redox score ?
nan
PDB code
4jcj
Structure name
crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Structure deposition date
2013-02-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
34
Peptide accession
P70662
Residue number A
273
Residue number B
67
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 273 of LIM domain-binding protein 1

Cysteine 67 of LIM domain-binding protein 1

Uncertain whether structure cysteine 58 has been assigned to correct residue.
Cysteine 67 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 87 and 159 (87 and 112 respectively in this structure).

Details

Redox score ?
nan
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
11
Peptide accession
P70662
Residue number A
87
Residue number B
159
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 87 of LIM domain-binding protein 1

Cysteine 159 of LIM domain-binding protein 1

Cysteine 87 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 112 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 33 and 269 (33 and 56 respectively in this structure).

Details

Redox score ?
nan
PDB code
1j2o
Structure name
structure of flin2, a complex containing the n-terminal lim domain of lmo2 and ldb1-lid
Structure deposition date
2003-01-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
28
Peptide accession
P70662
Residue number A
33
Residue number B
269
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 33 of LIM domain-binding protein 1

Cysteine 269 of LIM domain-binding protein 1

Cysteine 33 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 56 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 90 and 159 (90 and 112 respectively in this structure).

Details

Redox score ?
nan
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
2
Peptide accession
P70662
Residue number A
90
Residue number B
159
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 90 of LIM domain-binding protein 1

Cysteine 159 of LIM domain-binding protein 1

Cysteine 90 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 112 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 38 and 269 (38 and 56 respectively in this structure).

Details

Redox score ?
nan
PDB code
1j2o
Structure name
structure of flin2, a complex containing the n-terminal lim domain of lmo2 and ldb1-lid
Structure deposition date
2003-01-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
18
Peptide accession
P70662
Residue number A
38
Residue number B
269
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 38 of LIM domain-binding protein 1

Cysteine 269 of LIM domain-binding protein 1

Cysteine 38 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 56 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 45 and 273 (45 and 58 respectively in this structure).

Details

Redox score ?
nan
PDB code
4jcj
Structure name
crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Structure deposition date
2013-02-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
51
Peptide accession
P70662
Residue number A
45
Residue number B
273
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 45 of LIM domain-binding protein 1

Cysteine 273 of LIM domain-binding protein 1

Cysteine 45 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 58 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 115 and 118.

Details

Redox score ?
nan
PDB code
1rut
Structure name
complex of lmo4 lim domains 1 and 2 with the ldb1 lid domain
Structure deposition date
2003-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
8
Peptide accession
P70662
Residue number A
115
Residue number B
118
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 115 of LIM domain-binding protein 1

Cysteine 118 of LIM domain-binding protein 1

Cysteine 115 in protein A could not be asigned to a Uniprot residue.
Cysteine 118 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 33 and 36.

Details

Redox score ?
nan
PDB code
1j2o
Structure name
structure of flin2, a complex containing the n-terminal lim domain of lmo2 and ldb1-lid
Structure deposition date
2003-01-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
15
Peptide accession
P70662
Residue number A
33
Residue number B
36
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 33 of LIM domain-binding protein 1

Cysteine 36 of LIM domain-binding protein 1

Cysteine 33 in protein A could not be asigned to a Uniprot residue.
Cysteine 36 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 48 and 67.

Details

Redox score ?
nan
PDB code
4jcj
Structure name
crystal structure of isl1 lim domains with ldb1 lim-interaction domain
Structure deposition date
2013-02-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
nan
Peptide accession
P70662
Residue number A
48
Residue number B
67
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 48 of LIM domain-binding protein 1

Cysteine 67 of LIM domain-binding protein 1

Cysteine 48 in protein A could not be asigned to a Uniprot residue.
Cysteine 67 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 94 and 269 (94 and 119 respectively in this structure).

Details

Redox score ?
nan
PDB code
2l6z
Structure name
haddock model of gata1nf:lmo2lim2-ldb1lid with fog
Structure deposition date
2010-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
15
Peptide accession
P70662
Residue number A
94
Residue number B
269
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 94 of LIM domain-binding protein 1

Cysteine 269 of LIM domain-binding protein 1

Cysteine 94 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 119 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 36 and 269 (36 and 56 respectively in this structure).

Details

Redox score ?
nan
PDB code
1j2o
Structure name
structure of flin2, a complex containing the n-terminal lim domain of lmo2 and ldb1-lid
Structure deposition date
2003-01-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
20
Peptide accession
P70662
Residue number A
36
Residue number B
269
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 36 of LIM domain-binding protein 1

Cysteine 269 of LIM domain-binding protein 1

Cysteine 36 in protein A could not be asigned to a Uniprot residue.
Uncertain whether structure cysteine 56 has been assigned to correct residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 94 and 97.

Details

Redox score ?
nan
PDB code
2l6y
Structure name
haddock model of gata1nf:lmo2lim2-ldb1lid
Structure deposition date
2010-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
6
% buried
8
Peptide accession
P70662
Residue number A
94
Residue number B
97
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 94 of LIM domain-binding protein 1

Cysteine 97 of LIM domain-binding protein 1

Cysteine 94 in protein A could not be asigned to a Uniprot residue.
Cysteine 97 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 38 and 58.

Details

Redox score ?
nan
PDB code
1m3v
Structure name
flin4: fusion of the lim binding domain of ldb1 and the n-terminal lim domain of lmo4
Structure deposition date
2002-06-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
17
Peptide accession
P70662
Residue number A
38
Residue number B
58
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 38 of LIM domain-binding protein 1

Cysteine 58 of LIM domain-binding protein 1

Cysteine 38 in protein A could not be asigned to a Uniprot residue.
Cysteine 58 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within LIM domain-binding protein 1 between cysteines 122 and 144.

Details

Redox score ?
nan
PDB code
2l6z
Structure name
haddock model of gata1nf:lmo2lim2-ldb1lid with fog
Structure deposition date
2010-12-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
39
Peptide accession
P70662
Residue number A
122
Residue number B
144
Peptide name
LIM domain-binding protein 1

Ligandability

Cysteine 122 of LIM domain-binding protein 1

Cysteine 144 of LIM domain-binding protein 1

Cysteine 122 in protein A could not be asigned to a Uniprot residue.
Cysteine 144 in protein B could not be asigned to a Uniprot residue.
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