ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium/hydrogen exchanger 9B2

Intramolecular
Cysteine 217 and cysteine 289
Cysteine 212 and cysteine 217
A redox-regulated disulphide may form within Sodium/hydrogen exchanger 9B2 between cysteines 217 and 289. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7b4l
Structure name
cryoem structure of the human sodium proton exchanger nha2
Structure deposition date
2020-12-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
43
Peptide accession
Q86UD5
Residue number A
217
Residue number B
289
Peptide name
Sodium/hydrogen exchanger 9B2

Ligandability

Cysteine 217 of Sodium/hydrogen exchanger 9B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 289 of Sodium/hydrogen exchanger 9B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium/hydrogen exchanger 9B2 between cysteines 212 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7b4m
Structure name
cryoem structure of the human sodium proton exchanger nha2 in nanodisc
Structure deposition date
2020-12-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
56
Peptide accession
Q86UD5
Residue number A
212
Residue number B
217
Peptide name
Sodium/hydrogen exchanger 9B2

Ligandability

Cysteine 212 of Sodium/hydrogen exchanger 9B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Sodium/hydrogen exchanger 9B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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