a tool for identifying drug-targetable redox-active disulphides

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Intramolecular

Cysteine 637 and cysteine 641

A redox-regulated disulphide may form within Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 between cysteines 637 and 641 (45 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

solution structure of the second pdz domain of human membrane associated guanylate kinase inverted-2 (magi-2)

Structure deposition date

2003-08-11

Thiol separation (Å)

9

Half-sphere exposure sum ?

51

Minimum pK_a ?

9

% buried

18

Peptide accession

Residue number A

637

Residue number B

641

Peptide name

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Ligandability

Cysteine 637 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 641 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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