ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Reticulon-4 receptor-like 2

Intramolecular
Cysteine 267 and cysteine 310
Cysteine 31 and cysteine 37
Cysteine 35 and cysteine 46
Cysteine 265 and cysteine 288
Cysteine 31 and cysteine 35
Cysteine 35 and cysteine 37
Cysteine 37 and cysteine 46
Cysteine 31 and cysteine 46
A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 267 and 310.

Details

Redox score ?
88
PDB code
4p8s
Structure name
crystal structure of nogo-receptor-2
Structure deposition date
2014-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
267
Residue number B
310
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 267 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 31 and 37.

Details

Redox score ?
87
PDB code
4p8s
Structure name
crystal structure of nogo-receptor-2
Structure deposition date
2014-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
31
Residue number B
37
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 31 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 35 and 46.

Details

Redox score ?
84
PDB code
4p91
Structure name
crystal structure of the nogo-receptor-2 (27-330)
Structure deposition date
2014-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
35
Residue number B
46
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 35 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 265 and 288.

Details

Redox score ?
83
PDB code
4p8s
Structure name
crystal structure of nogo-receptor-2
Structure deposition date
2014-04-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
265
Residue number B
288
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 265 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 31 and 35.

Details

Redox score ?
66
PDB code
4p91
Structure name
crystal structure of the nogo-receptor-2 (27-330)
Structure deposition date
2014-04-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
31
Residue number B
35
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 31 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 35 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 35 and 37.

Details

Redox score ?
62
PDB code
4p8s
Structure name
crystal structure of nogo-receptor-2
Structure deposition date
2014-04-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
35
Residue number B
37
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 35 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 37 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4p91
Structure name
crystal structure of the nogo-receptor-2 (27-330)
Structure deposition date
2014-04-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
37
Residue number B
46
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 37 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor-like 2 between cysteines 31 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4p91
Structure name
crystal structure of the nogo-receptor-2 (27-330)
Structure deposition date
2014-04-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WD1
Residue number A
31
Residue number B
46
Peptide name
Reticulon-4 receptor-like 2

Ligandability

Cysteine 31 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Reticulon-4 receptor-like 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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