a tool for identifying drug-targetable redox-active disulphides

Interferon alpha 2b

Intramolecular

Cysteine 30 and cysteine 139

A redox-regulated disulphide may form within Interferon alpha 2b between cysteines 30 and 139 (29 and 138 respectively in this structure).

Details

Redox score ?

85

PDB code

Structure name

human ifna2-ifnar ternary complex

Structure deposition date

2011-06-10

Thiol separation (Å)

2

Half-sphere exposure sum ?

58

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

30

Residue number B

139

Peptide name

Interferon alpha 2b

Ligandability

Cysteine 30 of Interferon alpha 2b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Interferon alpha 2b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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