a tool for identifying drug-targetable redox-active disulphides

NADPH oxidase activator 1

Intermolecular

Cysteine 451 and cysteine 451

A redox-regulated disulphide may form between two units of NADPH oxidase activator 1 at cysteines 451 and 451 (55 and 55 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

59

PDB code

Structure name

sh3 domain of nadph oxidase activator 1

Structure deposition date

2020-06-29

Thiol separation (Å)

5

Half-sphere exposure sum ?

56

Minimum pK_a ?

12

% buried

76

Peptide A name

NADPH oxidase activator 1

Peptide B name

NADPH oxidase activator 1

Peptide A accession

Peptide B accession

Peptide A residue number

451

Peptide B residue number

451

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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