ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-alpha-acetyltransferase 40

Intramolecular
Cysteine 204 and cysteine 209
Cysteine 204 and cysteine 205 L
A redox-regulated disulphide may form within N-alpha-acetyltransferase 40 between cysteines 204 and 209.

Details

Redox score ?
87
PDB code
4u9v
Structure name
crystal structure of natd (naa40p) bound to acetyl coa
Structure deposition date
2014-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86UY6
Residue number A
204
Residue number B
209
Peptide name
N-alpha-acetyltransferase 40

Ligandability

Cysteine 204 of N-alpha-acetyltransferase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of N-alpha-acetyltransferase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 40 between cysteines 204 and 205.

Details

Redox score ?
63
PDB code
7kd7
Structure name
crystal structure of human natd (naa40) bound to a bisubstrate analogue
Structure deposition date
2020-10-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
17
Minimum pKa ?
9
% buried
0
Peptide accession
Q86UY6
Residue number A
204
Residue number B
205
Peptide name
N-alpha-acetyltransferase 40

Ligandability

Cysteine 204 of N-alpha-acetyltransferase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of N-alpha-acetyltransferase 40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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