ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adiponectin receptor protein 2

Intramolecular
Cysteine 241 and cysteine 380
Cysteine 135 and cysteine 206
Cysteine 156 and cysteine 161
Cysteine 156 and cysteine 194
A redox-regulated disulphide may form within Adiponectin receptor protein 2 between cysteines 241 and 380.

Details

Redox score ?
84
PDB code
6ks1
Structure name
crystal structure of the human adiponectin receptor 2
Structure deposition date
2018-08-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
35
Minimum pKa ?
9
% buried
8
Peptide accession
Q86V24
Residue number A
241
Residue number B
380
Peptide name
Adiponectin receptor protein 2

Ligandability

Cysteine 241 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adiponectin receptor protein 2 between cysteines 135 and 206.

Details

Redox score ?
70
PDB code
5lxa
Structure name
crystal structure of human adiponectin receptor 2 in complex with a c18 free fatty acid at 3
Structure deposition date
2016-09-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
100
Peptide accession
Q86V24
Residue number A
135
Residue number B
206
Peptide name
Adiponectin receptor protein 2

Ligandability

Cysteine 135 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adiponectin receptor protein 2 between cysteines 156 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6ks1
Structure name
crystal structure of the human adiponectin receptor 2
Structure deposition date
2018-08-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
28
Peptide accession
Q86V24
Residue number A
156
Residue number B
161
Peptide name
Adiponectin receptor protein 2

Ligandability

Cysteine 156 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adiponectin receptor protein 2 between cysteines 156 and 194. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5lwy
Structure name
revised crystal structure of the human adiponectin receptor 2 in complex with a c18 free fatty acid
Structure deposition date
2016-09-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
77
Peptide accession
Q86V24
Residue number A
156
Residue number B
194
Peptide name
Adiponectin receptor protein 2

Ligandability

Cysteine 156 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Adiponectin receptor protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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