ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tubulinyl-Tyr carboxypeptidase 2

Intermolecular
Cysteine 158 and cysteine 450 of Tubulin alpha-1B chain
A redox-regulated disulphide may form between cysteine 158 of Tubulinyl-Tyr carboxypeptidase 2 and cysteine 450 of Tubulin alpha-1B chain.

Details

Redox score ?
83
PDB code
6j4v
Structure name
structural basis of tubulin detyrosination by vasohibins-svbp enzyme complex and functional implications
Structure deposition date
2019-01-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tubulinyl-Tyr carboxypeptidase 2
Peptide B name
Tubulin alpha-1B chain
Peptide A accession
Q86V25
Peptide B accession
P68363
Peptide A residue number
158
Peptide B residue number
450

Ligandability

Cysteine 158 of Tubulinyl-Tyr carboxypeptidase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of Tubulin alpha-1B chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 in protein B could not be asigned to a Uniprot residue.
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