ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Scavenger receptor cysteine-rich type 1 protein M130

Intramolecular
Cysteine 546 and cysteine 556
Cysteine 487 and cysteine 521
Cysteine 515 and cysteine 576
Cysteine 503 and cysteine 567
Cysteine 520 and cysteine 576
Cysteine 486 and cysteine 576
Cysteine 515 and cysteine 520
Cysteine 487 and cysteine 516
A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 546 and 556.

Details

Redox score ?
89
PDB code
5jfb
Structure name
crystal structure of the scavenger receptor cysteine-rich domain 5 (srcr5) from porcine cd163
Structure deposition date
2016-04-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VL90
Residue number A
546
Residue number B
556
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 546 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 556 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 487 and 521.

Details

Redox score ?
85
PDB code
6k0l
Structure name
the crystal structure of simian cd163 srcr5
Structure deposition date
2019-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VLG4
Residue number A
487
Residue number B
521
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 487 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 521 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 515 and 576.

Details

Redox score ?
84
PDB code
5jfb
Structure name
crystal structure of the scavenger receptor cysteine-rich domain 5 (srcr5) from porcine cd163
Structure deposition date
2016-04-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VL90
Residue number A
515
Residue number B
576
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 515 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 576 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 503 and 567.

Details

Redox score ?
80
PDB code
6k0l
Structure name
the crystal structure of simian cd163 srcr5
Structure deposition date
2019-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VLG4
Residue number A
503
Residue number B
567
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 503 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 567 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 520 and 576.

Details

Redox score ?
71
PDB code
5hrj
Structure name
crystal structure of the scavenger receptor cysteine-rich domain 5 (srcr5) from porcine cd163
Structure deposition date
2016-01-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VL90
Residue number A
520
Residue number B
576
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 520 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 576 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 486 and 576.

Details

Redox score ?
64
PDB code
5jfb
Structure name
crystal structure of the scavenger receptor cysteine-rich domain 5 (srcr5) from porcine cd163
Structure deposition date
2016-04-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VL90
Residue number A
486
Residue number B
576
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 486 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 576 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 515 and 520. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5hrj
Structure name
crystal structure of the scavenger receptor cysteine-rich domain 5 (srcr5) from porcine cd163
Structure deposition date
2016-01-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VL90
Residue number A
515
Residue number B
520
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 515 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 520 of Scavenger receptor cysteine-rich type 1 protein M130

A redox-regulated disulphide may form within Scavenger receptor cysteine-rich type 1 protein M130 between cysteines 487 and 516. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6k0l
Structure name
the crystal structure of simian cd163 srcr5
Structure deposition date
2019-05-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2VLG4
Residue number A
487
Residue number B
516
Peptide name
Scavenger receptor cysteine-rich type 1 protein M130

Ligandability

Cysteine 487 of Scavenger receptor cysteine-rich type 1 protein M130

Cysteine 516 of Scavenger receptor cysteine-rich type 1 protein M130

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